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02-08-2017, 03:45 AM | #1 | ||
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Zinc levels in Parkinson's patients much lower than healthy controls:
Association Between Serum Zinc Levels and the Risk of Parkinson's Disease: a Meta-Analysis. - PubMed - NCBI |
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02-08-2017, 09:45 AM | #2 | ||
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Senior Member
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A broader discussion of serum metal levels in PD can be found in a thread from 2012:
Serum metal levels To quote from that thread: Ahmed and Santosh [1] measured the serum levels of various metals in PD (n=45) and non-PD (n=42) people in South India. They found that "Al [high in PwP], Cu [high], Fe [low], Mn [high] and Zn [low] were dominantly reponsible for the separation of PD from normal". They went on to look at the correlation between metal ratios and PD: "Al/Cu, Al/Fe, Al/Mn, Al/Zn, Cu/Fe, Cu/Zn, Fe/Zn and Mn/Zn were increased and Fe/Mn and Cu/Mn were decreased in PD compared to healthy control". They describe a neural network (a computing technique, ironically inspired by the working of the brain) which, taking together all the relationships, gives a 95% diagnostic accuracy. (But, note the small sample size.) Reference [1] Ahmed SSSJ, Santosh W (2010) Metallomic Profiling and Linkage Map Analysis of Early Parkinson's Disease: A New Insight to Aluminum Marker for the Possible Diagnosis. PLoS ONE 5(6): e11252. doi:10.1371/journal.pone.0011252 400 Bad Request John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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02-08-2017, 06:26 PM | #3 | |||
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Grand Magnate
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I think that this is interesting.
It has been known for some time that α-synuclein can bind a range of metal ions. It has been argued that this may lead to production of Reactive Oxygen Species (ROS) which may lead to neuronal damage in people with PD; this is a recent, somewhat technical, paper about this Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. It is possible (though speculative) that the low levels of Zn2+ in people with PD may allow α-synuclein to preferentially interact with redox-active metal ions like Fe3+ and Cu2+, leading to generation of ROS.
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02-09-2017, 06:35 AM | #4 | ||
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Senior Member
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I've not done one of these geographical associations for some time. I find them useful not so much as proof, which of course they aren't - there is no rigorous statistical analysis, nor does it take into account any of a myriad of confounding issues - but to kick-out obviously flawed hypotheses.
Compare: A. The geographical prevalence of PD in the US [1]. B. Zinc in the soil in the US [2]. Eye-balling the maps I suspect that there is a small negative association between the two. Thus, we can't throw out the hypothesis that low levels of zinc are linked to PD. I would suspect that the causal mechanism by which zinc levels in the body associate with those in the soil is through the food chain and the water supply. References: [1] "Geographic and Ethnic Variation in Parkinson Disease: A Population-Based Study of US Medicare Beneficiaries" Allison Wright Willis,a,* Bradley A. Evanoff,b Min Lian,b Susan R. Criswell,a and Brad A. Racette Geographic and Ethnic Variation in Parkinson Disease: A Population-Based Study of US Medicare Beneficiaries Figure 1. [2] "Element Concentrations in Soils and Other Surficial Materials of the Conterminous United States" US Geological Survey https://pubs.usgs.gov/pp/1270/pdf/PP1270_508.pdf Original page 102 John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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02-13-2017, 02:38 AM | #5 | ||
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Junior Member
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Quote:
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