Home Menu

Site Navigation



Parkinson's Disease Tulip


advertisement
NeuroTalk Support Groups > > >

Prothena Phase 1B study of Alpha Synuclein and Parkinsons! Yeah!

Reply
Page 2 of 2 1 2
 
Thread Tools Display Modes
Old 04-04-2017, 10:18 PM #11
Tupelo3 Tupelo3 is offline
Member
  
Join Date: Mar 2013
Location: New Jersey
Posts: 832
10 yr Member
Tupelo3 Tupelo3 is offline
Member
 
Join Date: Mar 2013
Location: New Jersey
Posts: 832
10 yr Member
Default
Quote:
Originally Posted by jeffreyn View Post
Blackfeather said: ".... an aggegation of alpha synuclean in the brain results in PD."

As Tupelo3 said: "Let's just hope that it actually has efficacy."

IMHO, they might end up (eventually) finding that PD results in an aggregation of alpha synuclein in the brain, rather then an aggregation of alpha synuclein in the brain results in PD.
No doubt that there are legitimate arguments for both schools of thought, although the misfolded a-syn aggregation leading to cell death camp is clearly the larger one at this time (neither side having actual proof).

As I said, all of the Alzheimer's research has failed to date. Could be that the drugs just don't work in the cell like they do in cerebral fluid ; could be it attacks the wrong protein ; or it could be that the protein aggregation is just a by-product of the disease and not part of the causal sequence.
Tupelo3 is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
jeffreyn (04-04-2017)

advertisement
Old 06-22-2018, 09:47 PM #12
jeffreyn jeffreyn is offline
Member
  
Join Date: Apr 2016
Location: Australia
Posts: 352
8 yr Member
jeffreyn jeffreyn is offline
Member
 
Join Date: Apr 2016
Location: Australia
Posts: 352
8 yr Member
Default Finally, an update!
This recent article from AlzForum gives an update on PRX002 (plus discussion and comments).

α-Synuclein Antibody Appears Safe, Reaches Brain | ALZFORUM
jeffreyn is offline   Reply With QuoteReply With Quote
Old 06-23-2018, 09:58 PM #13
jeffreyn jeffreyn is offline
Member
  
Join Date: Apr 2016
Location: Australia
Posts: 352
8 yr Member
jeffreyn jeffreyn is offline
Member
 
Join Date: Apr 2016
Location: Australia
Posts: 352
8 yr Member
Default
This post on the SoPD blog covers the recently-released PRX002 Phase 1b results (and includes a lot of background information).

Prothena: Phase I results published | The Science of Parkinson's
jeffreyn is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
kiwi33 (06-24-2018)
Old 06-24-2018, 01:45 AM #14
kiwi33's Avatar
kiwi33 kiwi33 is offline
Grand Magnate
  
Join Date: Jan 2015
Location: Sydney, Australia.
Posts: 3,093
8 yr Member
kiwi33 kiwi33 is offline
Grand Magnate
kiwi33's Avatar
 
Join Date: Jan 2015
Location: Sydney, Australia.
Posts: 3,093
8 yr Member
Default
Jeffreyn, the more I read from SoPD the more impressed I am.

Your latest link is a good example. It describes some complex ideas from immunology and protein misfolding in a non-technical way which is clear and accurate (my colleagues and I worked in these fields and published quite a few papers on them).

I hope that the latest work turns out to be helpful to people with PD.
__________________
Knowledge is power.
kiwi33 is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
jeffreyn (06-24-2018)
Reply
Page 2 of 2 1 2

Tags
alpha, parkinsons, phase, synuclein, yeah

« Previous Thread | Next Thread »
Thread Tools
Display Modes
Linear Mode Linear Mode

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts
BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Similar Threads
Thread Thread Starter Forum Replies Last Post
Prothena reports 97 % reduction of alpha synuclein after 1 dose! zanpar321 Parkinson's Disease 6 11-23-2016 03:48 PM
Study Refutes Prion Theory of Alpha-Synuclein Aggregates in Parkinson's Disease badboy99 Parkinson's Disease 0 01-08-2016 12:53 PM
Prothena initiates 2nd phase 1 study of PRX002 - another A-Syn antibody Tupelo3 Parkinson's Disease 0 07-31-2014 08:33 PM
First human dosed in Phase 1 trial of antibody targeting alpha synuclein olsen Parkinson's Disease 0 04-10-2014 02:22 AM
Alpha-synuclein Diego24 Parkinson's Disease 6 07-14-2012 11:59 PM


All times are GMT -5. The time now is 03:05 AM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

All posts copyright their original authors.

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.

Always consult your doctor before trying anything you read here.

Home