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03-26-2017, 06:08 AM | #11 | ||
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Tupelo3, I've read your response several times, but I just can't see how you came to understand my post in that way. I'll try to say the same thing once again, but this time in a different way.
From reference [4]: "While the activity of c-Abl is crucial for proper neuronal development, it appears that c-Abl remains relatively quiescent in healthy adult neurons, and there are few known functions of c-Abl in fully differentiated neurons. In recent years, it has been shown that activation of c-Abl in adult brain occurs in the context of human neurodegenerative disease." From reference [2]: "c-Abl is a nonreceptor tyrosine kinase that is activated by oxidative and cellular stress" Just from these two statements, it could be hypothesized that the inhibition of c-Abl might be a worthwhile thing to try. I have simply outlined three different ways by which the inhibition of c-Abl might (hypothetically) result in protection of dopamine neurons. Granted, hypotheses 1 & 3 have my name on them, but in each case I have only contributed the bit which says that c-Abl prevents Parkin from performing its normal function. The rest of hypothesis 1 and hypothesis 3 is straight from reference [1] and reference [3] respectively. [1] Matheoud et al. (2016) Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation, Cell 166, 314–327, doi: 10.1016/j.cell.2016.05.039. [2] Brahmachari et al. (2016) Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration, J Clin Invest. doi: 10.1172/JCI85456. [3] Yunjong et al. (2016) PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival, Cell Reports Volume 18, Issue 4, p918–932, doi: 10.1016/j.celrep.2016.12.090. [4] Schlatterer et al. (2011) c-Abl in Neurodegenerative Disease, J Mol Neurosci. 2011 Nov; 45(3): 445–452, doi: 10.1007/s12031-011-9588-1. |
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"Thanks for this!" says: | Tupelo3 (03-26-2017) |
03-26-2017, 08:21 AM | #12 | ||
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I guess we'll just have to agree to disagree.
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03-26-2017, 09:02 AM | #13 | ||
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Quote:
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03-26-2017, 06:43 PM | #14 | ||
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Tupelo3 said: "I guess we'll just have to agree to disagree."
Okay, let's do that for now. It concerns me though, that I find myself disagreeing with you. I shall spend some time trying to deepen my understanding of this area. |
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"Thanks for this!" says: | Tupelo3 (03-26-2017) |
03-26-2017, 06:56 PM | #15 | ||
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This whole thing was probably just a difference in semantic interpretation. Nevertheless, I would be happy to discuss this with you more off-line at anytime so we can educate each other Gary |
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"Thanks for this!" says: | jeffreyn (03-26-2017) |
03-30-2017, 08:20 AM | #16 | |||
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I, too, seem to be germ proof. I haven't had a cold in years since being diagnosed and don't catch them even when everyone around me has a cold or flu.
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Born 1948. Diagnosed 2011. DBS ON 7/17. Taking cd/ld 200 MG at 6 am, 9 am, 12 pm, 3 pm, 6 pm and 9 pm. Finasteride 5 mg, Life Extension Mix and Once-Daily Health Booster, Mitochondrial Energy Optimizer with BioPQQ, Optimized Curcumin (longvida), Triple Action Cruciferous Vegetable Extract with Resveratrol, Vectomega-3, Vit D3 5000U,Lithium orotate 5 mg, AMPK Activator, Kefiran, N-Acetyl-L- Cysteine (NAC), Tri-Magnesium, Advanced NeuroPro, Duozyme, Palmitoylethanolamide (PEA) Updated 9/21/17. |
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