Very interesting KNVP! I've personally considered starting 20mg/day Doxy for my PD. I guess I would generally expect, if it works, that you might observe that your PD would stop progressing, which would probably require many months to be apparent.

I certainly hope your DIY experiment is successful! I have additional thoughts/questions. Please PM me if you have a minute.

Sure you can private message me. I am off the computer for a few days except for checking a few things. I have trouble with my eyes if I look at a screen too much. Then I have to stay away for a while.

Well, you are right about being patient with results. Did you see my post on NTcell and stopping progression? NZ company and they seem to be doing well.

I don't recall seeing a post about your eyes so far. So now I need to ask if you have headaches with your eye problems?

Chronic use of the tetracycline family (minocycline and doxycyline) can trigger pseudotumor cerebri (intracranial hypertension) which can damage the optic nerves. So if you have not had evaluation for this, now is the time to do so.

KNPV, I've been unable to figure out how to PM on this forum. Do you know if it is possible to PM?
Thanks!

Hello PDman

The forum has a default number of posts required before new members can PM
Once you reach that, the PM system will open up for you.

At the rate my PD progression is going, in a year or so I may be dead or in a nursing home for indigent patients, wheel chair bound, stuck in a corner, heavily drugged and drooling. As we know, there aren't many drug options on the table that can potentially slow or stop this progression. I am willing to take a chance on doxycycline. I believe my primary care doc will prescribe it for me. At this stage of the game there's not much for me to lose.

Hi Blackfeather,
Sorry not up on Doxycycline so won't comment on it.
Blackfeather, maybe you have a bit of depression?
Do you see a movement disorder specialist for management of P.D.?
If not it might be worthwhile.
As far as Drs in general practice go which I think a primary care physician is I'd be more inclined to hear what an MDS who lives and breathes P.D. would come up with plus other medical staff like a speech therapist, physiotherapist, occupational therapist who specialise in P.D.

Yes, I am suffering from depression, more than a bit, though. The depression and anxiety are very intense. I have been experiencing non motor PD symptoms beginning more than 2 decades ago, such as insomnia, fatigue, depression, gastro intestinal problems and others. Last six years I have the classic motor symptoms. Can't remember when life was normal. My primary care phys. Is a wise older gent who I think will be more familiar with doxy than my Movement disorder specialist. Therapy won't help much I'm afraid. Thanks!

Doxycycline and PD
 

I'm starting to take 20 mg/day doxycycline, and I'm continuing to discuss the pros and cons of this with my neurologist.

Still taking 20 mg/day of doxy, no ill effects observable.