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05-04-2017, 09:52 AM | #1 | ||
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05-06-2017, 12:42 AM | #2 | ||
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From the research paper:
"The results presented herein reveal potential protective side effects for doxycycline in the pathogenesis cycle of synucleinopathies that could be exploited repurposing an old safe drug." "This data strongly suggests that doxycycline in subantibiotic doses (20–40 mg/day) would be enough to exert neuroprotection." From the ScienceDaily article: "This treatment could stop Parkinson's from progressing, and we therefore plan to start a clinical trial shortly." Could this be another clinical trial worthy of a fast-track process? Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species : Scientific Reports (this is an open-access research paper) |
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"Thanks for this!" says: | kiwi33 (05-06-2017) |
05-06-2017, 03:32 AM | #3 | |||
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Grand Magnate
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An impressive piece of biophysics and cell biology.
I think that the comments in the link are worth considering.
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Knowledge is power. |
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05-06-2017, 07:22 AM | #4 | ||
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Well spotted, kiwi33. I missed those comments, and they are significant.
It would seem that a fast-tracked clinical trial would not be appropriate. |
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"Thanks for this!" says: | Tupelo3 (05-06-2017) |
05-06-2017, 09:11 AM | #5 | ||
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05-06-2017, 10:15 PM | #6 | ||
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No worries, Tupelo3.
When I wrote those words, I had in the back of my mind the recent discussions about the desirability of speeding up the clinical-trials phase for PD drugs in general. So it wasn't that this one stood out particularly (although it did seem like a good candidate), it was more that I'd lowered the bar! The question mark at the end was (secret?) code for "I'm interested in a discussion". :-) But after that, kiwi33 alerted me to some expert comments, which shed new light on things. |
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05-06-2017, 09:09 AM | #7 | ||
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Quote:
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06-04-2017, 04:34 PM | #8 | ||
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I started taking 20 mg a day of Doxy about a week ago. So far, no observable effects.
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"Thanks for this!" says: | GerryW (06-07-2017) |
06-07-2017, 04:01 PM | #9 | ||
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I certainly hope your DIY experiment is successful! I have additional thoughts/questions. Please PM me if you have a minute. |
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06-07-2017, 10:48 PM | #10 | ||
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Well, you are right about being patient with results. Did you see my post on NTcell and stopping progression? NZ company and they seem to be doing well. |
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