FAQ/Help |
Calendar |
Search |
Today's Posts |
06-12-2017, 06:44 PM | #1 | ||
|
|||
Senior Member
|
As I understand it, there are two distinct mechanisms which have been used to reduce the peripheral metabolism of levodopa:
- DDC inhibitor (e.g carbidopa). Carbidopa [1] "inhibits aromatic-L-amino-acid decarboxylase (DOPA decarboxylase or DDC), ... an enzyme important in the ... biosynthesis of L-DOPA to dopamine (DA). DDC exists both outside of (body periphery) and within the confines of the blood brain barrier." - COMT inhibitor (e.g. entacapone). Entacapone [2] "is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT)... When taken together with levodopa (L-DOPA) and carbidopa, entacapone stops catechol-O-methyltransferase from breaking down and metabolizing levodopa, resulting in an overall increase of levodopa remaining in the brain and body." So, there's Sinemet (= levodopa + carbidopa) and Stalevo (= levodopa + carbidopa + entacapone). But, I've never seen levodopa + entacapone (i.e. without carbidopa). Why is this? References: [1] Carbidopa - Wikipedia [2] Entacapone - Wikipedia John
__________________
Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg Last edited by johnt; 06-12-2017 at 06:50 PM. Reason: typo |
||
Reply With Quote |
|
|
Similar Threads | ||||
Thread | Forum | |||
Pain-RX - Cox 2 Inhibitor | Vitamins, Nutrients, Herbs and Supplements | |||
LRRK2 inhibitor may slow progression for all PWPs | Parkinson's Disease | |||
Ace inhibitor? | Reflex Sympathetic Dystrophy (RSD and CRPS) | |||
Common Herbs With MAO Inhibitor Activity | Parkinson's Disease | |||
FP0011 can be a potent, safe glutamate release inhibitor | Parkinson's Disease |