Has anyone tried either i.v. or liposomal glutathione? With what results? My physician suggested Dr. David Perlmutter's book on neurological conditions, which strongly recommends glutathione. I've Looked through past threads on this and other sites and haven't come across much first-hand experience. It's quite costly in either form, so I'd be glad for any recommendations. Thanks.

(following is liberated from: Pre-treatment with R-Lipoic Acid Alleviates the Effects of GSH Depletion in PC12 Cells: Implications for Parkinson’s Disease Therapy

S. Bharath, , 1, B. C. Cochran1, M. Hsu1, J. Liu2, 3, B. N. Ames2, 3 and J. K. Andersen1 )


"Oxidative stress is believed to play a key role in the degeneration of dopaminergic neurons in the substantia nigra (SN) of Parkinson’s disease (PD) patients. An important biochemical feature of PD is a significant early depletion in levels of the thiol antioxidant compound glutathione (GSH) which may lead to the generation of reactive oxygen species (ROS), mitochondrial dysfunction, and ultimately to subsequent neuronal cell death..."

I have read anecdotal accounts of glutathione IV helping individuals with PD (oral glutathione is deactivated in the gut--it is useless. If someone is attempting to sell you an oral preparation of glutathione, my advice would be to pass and get away from them as quickly as possible)
One of the neurologists we consulted, Dr. Catherine Wilner, Durango, Co (she practices Functional Medicine--though is an MD, Mayo Clinic trained neurologist) uses IV glutathione as a "test" for PD, much as other MDs use Sinemet as a test. She maintains that IV glutathione initially causes a burst of the substance from the Substantia Nigra, but it quickly becomes depleted and likened its use to "beating a dead horse" with repeated use--. Thus this is "our" anecdote.
As with many other therapies in PD, what works for some does not work for others--who knows. It may work long term for you--though it is expensive to obtain in Florida. There are reports of individual(s) obtaining IV glutathione preparation from Florida and having their own physician administer it, though I think this happened for a person whose husband was an MD. Have you a relative who could administer it?
There are some supplements which are thought to be precursors and /or assist in proper function of glutathione which one may take orally--R+-alpha lipoic acid is one of these, riboflavin (Vit B2) is another necessary substance for glutathione to work properly. There are other supplements and vitamins and minerals which assist in glutathione functioning--selenium is part of the enzyme glutathione peroxidase.
best of luck, madelyn

re-reading this post this AM and it does not make sense--IV glutathione results in a burst of DOPAMINE out of the dopamine neurons and with repeated use of glutathione, dopamine is much depleted and the therapy fails to work....
the study being conducted by one of hte medical centers in Florida was slated to start ~2yrs ago--wonder if there is any preliminary info from them???
madelyn

pwp that take iv glutathione. i get ashot twice a week. my wife does the injection and she had never done one before this. a friend thats a nurse showed her how the first time- realy, its not rocket science. although, i am 47 and very healthy, if i was very late in years or if i had difficult veins i guess i would look for a pro to administer my shots.

i believe in the glutathione, probably more as an acct of faith than exaustively researched and objectively proven. there has been one italian study done and there is another study in progress(miami?). perlmutter
believes in the stuff, he takes it himself, as well as his wife and two young children get weekly shots. they dont have pd.

i order the glutathione over the phone from the wellness pharmacy. the perscription is from perlmutter. i also get the syinges, needles, etc... there.

i would encourage you to look into it further.

I understand that glutathione is not customarily absorbed in the gut, but the liposomal version has an outer wall which is fat soluble and an inner wall that is water soluble which supposedly makes it more bio-available. FOr convenience's sake I'd prefer the oral route, but it is this "supposedly" part that has me wondering if there is some clinical trials out there. Thanks to Madelyn for the info on the dopamine-depletive aspect of glutathione. I hadn't heard that one before, so I'll see get some verification. Stay tuned.