The focus of the first video was umbilical cord mesenchymal stem cells (MSCs), and their use in the treatment of conditions/diseases not including PD.

The focus of the following video is induced pluripotent stem cells (IPSCs), and their (future) use in the treatment of PD (mainly). The video is a recent interview with Dr. Jeanne Loring of Scripps Research Institute (8th June 2018, approx. 30 mins).

Facebook

Thanks jeffreyn.

I heard Dr Loring give a talk at a conference once; I was very impressed with her.

At 43+ minutes in reference was made to ALL chronic degenerative disease (your link to Joe Rogan /Mel Gibson longer video ) for (possibly creative??)application of (MSC) stem cells.

When I used the phrase "not including PD", I just meant that PD was not one of the conditions/diseases mentioned in the video.

I think you are right to suggest that MSCs might be of benefit in the treatment of PD.

My understanding of MSCs (from the video) is that they are found throughout the body, they modulate the immune system, decrease inflammation, and stimulate regeneration. They do not transform into other types of cell. Their influence occurs via the production of cytokines and growth factors.

Stem cells sourced from our own body verses cells sourced from another raises so many questions - more questions than answers but isn't it interesting that we have a way to optimize our own potential completely within us yet nature is also at the same time interdependent...building a more robust spacial semantic where both are true seems to be such a struggle.

This review of MSCs may be of interest Human mesenchymal stem cells - current trends and future prospective.

Most of the work has come from animal models so may or may not be relevant to people.

There are some ongoing clinical trials but no results seem to be available yet.

Here is my two cents worth on (umbilical cord) mesenchymal stem cells (MSCs) and induced pluripotent stem cells (IPSCs).

There is a theory that chronic neuroinflammation in PD is a result of chronic inflammation in the gut. Assuming that this is correct, it is conceivable that MSCs (perhaps given intravenously) might be able to halt the inflammation in the gut, thereby possibly bringing to a halt the inflammation in the brain. This would be a form of neuroprotection, possibly halting/slowing the progression of the disease.

For those PwPs in more advanced stages of the disease, neuroprotection is not sufficient. What is required is neuroregeneration, possibly via new dopamine neurons made from IPSCs.

NB: I haven't read any of the papers on MSCs yet, so my view is likely to change!

The gut inflammation:PD link sounds plausible to me. Here is a discussion of it https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445611/.

I reckon that MSCs and IPSCs are well worth thinking about in this context

What if this more generalized stimulus could catalyze/engage the autonomic nerve system to repair what is needed?

What if this more gereneralized stimulus could catalyze/engage the autonomic nerve system to do the needed (specific)repair?