1. I will pay privately for a C/L fill in order to have 1 or 2 month reserve in case there is a shortage, like the the MYLAN shortage recently caused by the hurricane in puerto rico. 25/250 costs just a few dollars more than 25/100 C/L. It has less carbidopa, so if you use it you might have to adjust the dosage.
2. It splits into 125mg and 62.5mg pieces which gives you more options if you take it with 25/100 C/L. With the 2 strengths, you can have 50mg, 62.5mg, 100mg, 112.5mg, 125mg, 162.5mg, 175mg, 187.5mg, 200mg, 225mg, 250mg, 262.5mg doses.
3. if you are partial to one brand, you might be able to get the 25/250 if the 25/100 is unavailable.

soccertese,

Although, by taking fractions from the two sizes of pill, you can get many different dosages, these have different ratios of levodopa and carbidopa. For instance, you can get 100mg from the 25/100 pill, L/C ratio 4:1; and 125mg from half the 25/250 pill, L/C ratio 10:1. But, it's not clear what would have a bigger effect.

Do you adjust both the size of the levodopa dose and the L/C ratio?

John

i look mainly at the l-dopa content but to be safe i start the mornng with 150mg of 25/100 to load up on carbidopa and will follow with 125mg (1/2 of a 250). after 60minutes i'll take 65mg + 50/200CR. Then i repeat this pattern, trying not to take (2) 50/200's consecutively since that can result in dyskinesias, it stays around for awhile. If i have to increase a dose because i want to overcome the negative affects of eating too much protein, i'll increase my C/L by using a 25/250. I'm using the 25/250 to try to save from using up 25/100 which works the best so i do use 25/250 daily and treat it just like a 25/100 but if i have to be at my best i'll just use 25/100.

so i haven't done any calculations or tests on trying to figure out how much 25/250 i need to take to get the same affect as 25/100. i don't have problems taking 125mg and will take a 250mg 25/250 if i ate too much protein and want to go ON sooner than waiting 2 hours after eating before taking your next C/L. It's not a perfect systgem but it's a cheap way to save up 25/100 which has been in short supply twice in the last year, which is significant for me since i do the best on their products.

in the u.s., even if you don't want to take 25/250, daily, it does offer a cheap way to build up a reserve of MYLAN C/L, that's the main point of my post. You could do the same with ACTIV, assuming they have 25/250 C/L. With fewer and fewer companies making C/L, and it's likely many are buying their ingredients from the same indian or chinese mfg's, having an extra fill or 2 around to me is just common sense.