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08-27-2018, 02:56 AM | #1 | ||
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A hydrogel is like a stronger version of jelly. More formally [1]:
"Hydrogels are three-dimensional, polymeric networks consisting of crosslinked hydrophilic components. In certain environmental conditions, hydrogels can imbibe large amounts of water or biological fluids, while remaining insoluble." They are excellent at soaking up a suitable drug and releasing it slowly. The only reference that I can find to hydrogels and Parkinson's is in a paper by Kondaveeti et al. [2]. Unfortunately, this is behind a paywall. But, from what I can gather, "levodopa is loaded into magnetic hydrogels". This is then released "under external magnetic field". Even without a magnetic effect, they draw a graph showing one of their gels delivering levodopa almost constantly for over a day. In my view, there would be considerable advantage in having a very slow delivery method for levodopa (that is, a long half-life), not because it might be more convenient, but because it might smooth out the peaks and troughs of plasma levodopa. This could reduce dyskinesia and/or allow PwP to take larger doses of levodopa without increasing the risk of dyskinesia. Reference: [1] "Therapeutic applications of hydrogels in oral drug delivery" Lindsey A Sharpe,1 Adam M Daily,1 Sarena D Horava,2 and Nicholas A Peppas Expert Opin Drug Deliv, 2014 Therapeutic applications of hydrogels in oral drug delivery [2] "Magnetic hydrogels for levodopa release and cell stimulation triggered by external magnetic field" Stalin Kondaveeti, Ana Teresa, Silva Semeano, Daniel R.Cornejo, Henning Ulrich, Denise Freitas Siqueira Petria Colloids and Surfaces B: Biointerfaces Volume 167, 1 July 2018, Pages 415-424 Magnetic hydrogels for levodopa release and cell stimulation triggered by external magnetic field - ScienceDirect John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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"Thanks for this!" says: | moondaughter (08-27-2018) |
08-27-2018, 09:05 AM | #2 | |||
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Quote:
I can only offer general thoughts but this is interesting. Lately I've been learning about the trouble "biofilms" cause in the body and elsewhere...a biofilm develops for example in a pets' watering bowl (if not cleaned often) - it is that slick icky feeling microfilm surface that collects bacteria etc. Would our epithelial linings rom our nose to our intestines be especially subject to develloping these??If so they must wreak havoc on the immune system amongst other things. I also see a sort of crust like surface that develops in garden soils that prevent water absorption. Imho when it comes to nutrient, absorption, can be more significant than intake in terms of revealing what can be effective. Kind Regards, MD
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Smooth seas do not make skillful sailors.... Nature loves courage. “The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.” ~ Nikola Tesla Last edited by moondaughter; 08-27-2018 at 11:40 AM. |
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08-27-2018, 11:42 AM | #3 | |||
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Speaking of magnetic fields and water absorption redox potential comes to mind.... How to measure a Redox Potential – The Laboratory People
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Smooth seas do not make skillful sailors.... Nature loves courage. “The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.” ~ Nikola Tesla |
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