Go Back   NeuroTalk Support Groups > >

Parkinson's Disease Tulip

Camicinal: reduces gastric emptying time

Reply
 
Thread Tools Display Modes
Old 09-07-2018, 02:02 AM   #1
johnt
Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 958
Default Camicinal: reduces gastric emptying time

Camicinal: reduces gastric emptying time

Most PwP will during their time with PD be prescribed with levodopa in one form or another. How the drug gets from the pill to the brain is very important. We focus here on the time it takes to get from the stomach to the upper intestines from where it can begin to be absorbed.

Marrinan et al. write [1]:

"Delayed gastric emptying may impair L-dopa absorption, contributing to motor fluctuations. We evaluated the effect of camicinal (GSK962040), a gastroprokinetic, on the absorption of L-dopa and symptoms of PD."

"Phase II, double blind, placebo controlled trial. Participants were randomized to receive camicinal 50mg once daily (n=38) or placebo (n=20) for 7 to 9 days."

"Camicinal resulted in significant reduction in OFF time (-2.31 hours ...), significant increase in ON time (+1.88 hours ...) per day, and significant decrease in mean total MD UPDRS score (-12.5 ...)."

Camicinal is a motilin receptor agonist, so it would be interesting to know the effect that motilin itself has on levodopa absorption.

Reference:

[1] "A randomized, double blind, placebo controlled trial of camicinal in Parkinson's disease"
Sarah L. Marrinan, MBBS, FRCP, MD, 1 , 2 Tal Otiker, MSc, 3 Lakshmi S. Vasist, PharmD, 4 Rachel A. Gibson, PhD, 3 Bhopinder K. Sarai, BSc (Hons), 5 Matthew E. Barton, PhD, 4 Duncan B. Richards, BM, BCh, DM, FRCP, 5 Per M. Hellström, MD, PhD, 6 Dag Nyholm, MD, PhD, 7 George E. Dukes, PharmD, 4 and David J. Burn, MD
Mov Disord, Feb 2018
A randomized, double‐blind, placebo‐controlled trial of camicinal in Parkinson's disease

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
johnt is offline   Reply With Quote
"Thanks for this!" says:
eds195 (09-07-2018)
Reply

Tags
absorption, camicinal, phd, placebo, time

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
SFN and Accelerated Gastric Emptying wildcovey Peripheral Neuropathy 0 02-25-2015 02:17 PM
Slow gastric emptying Shashi Multiple Sclerosis 3 07-02-2008 02:03 PM
Drug for MS Reduces Lesions and Extends Time to Relapse ZucchiniFlower Multiple Sclerosis 4 09-23-2006 10:39 AM


All times are GMT -5. The time now is 06:24 PM.
Brought to you by the fine folks who publish mental health and psychology information at Psych CentralMental Health Forums

The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider. Always consult your doctor before trying anything you read here.


Powered by vBulletin • Copyright ©2000 - 2018, Jelsoft Enterprises Ltd.
Search Engine Optimisation provided by DragonByte SEO v2.0.31 (Lite) - vBulletin Mods & Addons Copyright © 2018 DragonByte Technologies Ltd.

All posts copyright their original authors • Community GuidelinesTerms of UsePrivacy Policy