Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 10-27-2018, 02:42 AM #1
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
Default Measuring Parkinson's: UPDRS and MDS-UPDRS

There is no definitive way to measure Parkinson's. Two of the most often used methods are:
UPDRS, Unified Parkinson's Disease Rating Scale
MDS-UPDRS, Movement Disorder Society‐Sponsored Revision of the UPDRS.

(Note in both these measures low scores are good, since they show less disability.)

Each rating scale is formed from sections.

Each section is formed from questions/observations.

Each question is, usually at least, marked on a 5 point scale (0-4).

The maximum score, showing complete disability, for the UPDRS is 199 and for the MDS-UPDRS it is 272.

The first thing to do is note whether the score is "total" or some subset of the whole scale: Part III, motor scores are frequently reported.

UPDRS maximum section scores are as follows: Part I, 16 points; Part II, 52 points; Part III, 108 points; Part IV, 23.

You often read papers saying something like "the mean effect of this drug is to reduce UPDRS total score by 5 points".

Now, I think it is more likely that your personal measure of Parkinson's is made in percentage terms. For instance, you might think that your PD is 10% worse than it was a year ago.

So, to get a sense of a 5 point claim made in the literature you need to convert points score into a percentage score. Now the natural inclination is to divide 5 by 199 and multiply by 100 to get 2.51%. This isn't too impressive.

But, you make your assessment of the claim from where you are now compared with where you would be if you took the drug. So, suppose that your UPDRS score is now 50, the 5 point decrease would represent a 10% decrease. This is worth considering.

Holden et al. report the following results [1]:

"MDS‐UPDRS scores increased in a linear fashion over 5 years in patients with de novo PD. MDS‐UPDRS total scores increased an estimated 4.7 points per year, Part I scores increased 0.92 points per year, Part II scores increased 0.99 points per year, and Part III scores increased 2.4 points per year."

They show mean total MDS-UPDRS scores increasing from 31.75 at baseline, to 38.33, to 42.34, to 45.78, to 52.00, to 54.89 in the following 5 years.

Another thing to look out for is whether the results are based on medicated or non-medicated groups:

"The continuous linear time longitudinal model predicted an expected annual increase of 1.77 points ... for MDS‐UPDRS Part III for the medicated group. For the unmedicated group, Part III scores were predicted to increase by 4.02 points per year ... . There was a statistically significant difference in the slopes for MDS‐UPDRS Part III progression between the medicated and unmedicated groups, with an estimated difference of 2.25 points per year".

The MDS-UPDRS test can be seen at [2].

References:

[1] "Progression of MDS‐UPDRS Scores Over Five Years in De Novo Parkinson Disease from the Parkinson's Progression Markers Initiative Cohort"
Samantha K. Holden MD Taylor Finseth MD Stefan H. Sillau PhD Brian D. Berman MD
Movement Disorders Clinical Practice, September 2017
https://onlinelibrary.wiley.com/doi/...002/mdc3.12553

[2] https://www.movementdisorders.org/MD...lish_FINAL.pdf

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
johnt is offline   Reply With QuoteReply With Quote

advertisement
Reply

Tags
iii, increased, score, scores, updrs

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
NeuroMetrology Lab: measuring Parkinson's johnt Parkinson's Disease 0 11-08-2016 12:16 PM
Quantifying or measuring TOS? bwsnhp Thoracic Outlet Syndrome 0 05-10-2014 08:42 AM
Watch and learn: a new tool for measuring Parkinson’s disease soccertese Parkinson's Disease 4 07-12-2013 02:26 PM
Confused about the UPDRS rd42 Parkinson's Disease 1 10-19-2011 07:43 PM
UPDRS - Objectivity rd42 Parkinson's Disease 2 01-10-2011 06:33 PM


All times are GMT -5. The time now is 10:26 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.