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Role of alpha-synuclein, PARP and PAR in the death of neurons (via parthanatos) in PD

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Old 11-06-2018, 07:19 AM #1
jeffreyn jeffreyn is offline
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Default Role of alpha-synuclein, PARP and PAR in the death of neurons (via parthanatos) in PD
For those not put off already by the title, Simon does a great job of explaining another piece of the PD puzzle, via the following SoPD blog post:

We’re re-branding: It’s now called PARPinson’s | The Science of Parkinson's

The comment section of this SoPD blog post is also well worth a read. The following link is to an article referred to by Patrik Brundin in one of those comments:

Science Magazine - November 2, 218
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Old 11-12-2018, 09:00 PM #2
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Originally Posted by jeffreyn View Post
For those not put off already by the title, Simon does a great job of explaining another piece of the PD puzzle, via the following SoPD blog post:

We’re re-branding: It’s now called PARPinson’s | The Science of Parkinson's

The comment section of this SoPD blog post is also well worth a read. The following link is to an article referred to by Patrik Brundin in one of those comments:

Science Magazine - November 2, 2�18
Niraparib (zejula) was selected for funding at the most recent Linked Clinical Trials meeting (funding for repurposed drugs). It’s a really effective parp1 inhibitor. It was clearly the most interesting presentation, though a few others were also exciting. Look for announcement of a clinical trial to begin in 2019.
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Old 11-14-2018, 05:33 AM #3
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The cartoon of the different forms of cell death is excellent; I knew about some but not all of them.
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