Parkinson's Disease Tulip


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Old 11-09-2018, 03:25 AM #3
johnt johnt is offline
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johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
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Disappointing 1: the underlying paper is behind a paywall.

Disappointing 2: according to the New Daily article,
"The biggest hurdle, apart from funding, is that MCC950 came off a patent. This means the researchers have had to develop variations of the original drug for intellectual property reasons. Those new drugs are currently being tested and, according to Dr Woodruff, proving to be even more effective."

But, the good news is that there are plenty of natural compounds in this area. See [2].

Has anyone tried low dose aspirin?

References:

[1] "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice"
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice | Science Translational Medicine

[2] "Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production
József Tőzsér1 and Szilvia Benkő2
Mediators of Inflamation, Aug 2016
https://www.hindawi.com/journals/mi/2016/5460302/

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
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