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02-27-2019, 12:35 AM | #11 | ||
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Magnate
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TRYGUY,
IN LIEU OF taking an agonist at night to extend your ON time have you tried 300mg of 50/200er WITH A LITTLE OIL/FAT SUCH AS FISH oil capsule, butter/cracker, etc to try to slow gastric emptying which will extend the availability? just a theory. read a C/L PKG INSERT (ER) on bioavailability. or set an alarm at least 45min before you predict you'll be OFF, take 50mgIR + 200ER, THE IR should kick in in 45min and the ER in 90min. that might at least remove anxiety. you might have to wake up only once. Pharmacokinetics and bioavailability of Sinemet CR: a summary of human studies. - PubMed - NCBI |
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"Thanks for this!" says: | eds195 (03-01-2019) |
02-27-2019, 12:38 AM | #12 | ||
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Magnate
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Quote:
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03-09-2019, 04:20 PM | #13 | ||
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Soccer or anyone,
How long does the 50/200ER last for you at night and/or day. Neuro has me trying Rytary at night but not getting much out of it. Anyone have thoughts on the 50/200 vs. Rytary? Thanks, Eric |
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03-09-2019, 06:18 PM | #14 | |||
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Junior Member
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My precusors for seratonin, my own Dopamine and 300 other enzymes in pathways have been destroyed by neurologists. (The Machine) THESE ARE MY MAIN PROBLEMS. Medication induced neurodegenarative processes. Thank God they are reversible. It wont be easy but the alternative is a faster decline, way faster |
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03-09-2019, 09:17 PM | #15 | |||
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"Thanks for this!" says: | moondaughter (03-13-2019) |
03-10-2019, 10:41 AM | #16 | ||
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Magnate
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"Effect of Food As with carbidopa/levodopa IR, Rytary can be taken with or without food. One gets the quickest and most consistent (initial) absorption taking it away from food, but if a patient experiences nausea, taking it with carbohydrate may reduce the nausea. Protein can reduce absorption, but whether this is clinically relevant depends on how sensitive to small dose changes the patient is. Interestingly, high fat meals delay absorption and reduce the amount absorbed, but can potentially lengthen the duration of benefit. Although this has not yet been studied, one might take Rytary at bedtime with a high fat snack such as ice cream, in an effort to extend benefit into the night as long as possible. " How to Dose Rytary by Robert A. Hauser MD 3-12-15 | Medical Treatments | Medicine |
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"Thanks for this!" says: | eds195 (03-10-2019) |
03-10-2019, 06:20 PM | #17 | ||
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Member
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Soccer, thanks for taking the time. I will give the Rytary more of a chance and try it with a snack to delay absorption. I can eat half a cow 10 minutes after I take my usual dose of c/l and mucuna w/out a problem, but pay for it at the other end; sometimes up to 4 hours later after a medium/high protein meal meds still don't work, very frustrating. I try to be ON a bit when it's time for sleep so I can be comfortable enough to fall out, so the Rytary delay should not be a problem and could be a solution if it extends its usefulness.
Eric |
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03-11-2019, 09:16 AM | #18 | ||
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Magnate
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hopefully inhaled l-dopa and the sublingual apomorphine will help out as "rescue" drugs but the cost might be too high. |
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03-12-2019, 10:05 AM | #19 | ||
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I'm similar after dinner when one dose doesn't work I will keep adding smaller amounts in time frames you mention so that I can fall asleep without using up any of the dose I take right when the lights go out. Have eaten a fatty snack (Smart Balance on chips) last 2 nights just before Rytary dose and lights out. First night, 5 1/2 hours and last night 4 1/2 both followed by dose of c/l and mucuna and the nights were manageable, so thanks for the suggestion and Hauser/bioavailabilty links.
I just started the Requip xl 4mg up from 2mg which did nothing I could tell for 6 weeks but only a week in, will report back, hoping for something good out of this. Neuro says should round out my dopamine levels so I don't deplete so fast and crash which really rocked Jan/Feb with anxiety. Now I understand how bad those crashes made me feel and I've broken the vicious cycle of anxiety starting the moment I sense an off period coming, but still makes me shaky and mentally weaker. Definitely interested in the sublingual Apomorphine, which was delayed end of January by FDA.... Sunovion Receives Complete Response Letter from FDA for Apomorphine Sublingual Film (APL-13 277) | Sunovion Here is a guy who uses the Apomorphine pen in the UK, hat tip to John Morris over at HU. Watch video - FYI - Parkinson'''s Movement | HealthUnlocked Would be great if a rescue drug could help cut down on some of the crappy off periods you suspect are coming from a meal, first thing in morning or whenever. |
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"Thanks for this!" says: | soccertese (03-12-2019) |
03-12-2019, 07:15 PM | #20 | ||
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Senior Member
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To help answer some of the recent questions posed in this thread, you can use an app that I wrote to draw graphs of levodopa equivalent plasma levels during the day due to different drug regimen. This is based on the pharmacokinetic properties of the drugs used and the idea of levodopa equivalent dose (e.g 100mg of levodopa/carbidopa is "worth" approximately 5mg ropinirole).
Parkinson's Disease Measurement: PwP, surveys, trials, analysis Unfortunately, I've not been able to deal with Rytary within this framework. But, you can approximate one Rytary pill with four suitably timed and sized L/C IR pills. See, Approximating the pharmacokinetics of Rytary using IR C-L You're right the smoothing role played by ropinirole CR (Requip XL) is due to its longer half life. John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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"Thanks for this!" says: | eds195 (03-12-2019) |
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