Irreversible progressive neurodegeneration caused by PD is now understood to be in part reversible once the Carbidopa is stopped and the damage it has done is treated.

Removing carbidopa from treatment has the greatest positive outcome impact. Carbidopa’s ability to irreversibly bind with B6 and all B6-dependent enzymes can induce glutathione depletion, dopamine collapse, serotonin collapse, antihistamine-induced dyskinesias, and RNDs (reversible Neurodegeneration) contributing to these collapses. In turn, B6 depletion induces secondary function collapse involving over 300 enzyme and protein systems.

Carbidopa has been linked to the 328% increase in PD mortality which started the year after its introduction.

A lot of you must know this? Heres the title.

Parkinson’s disease managing reversible neurodegeneration