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06-21-2019, 06:02 AM | #1 | ||
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It's only a couple of days old, but there are quite a few articles on this already. This article is the most sober one I could find.
'Brain changes' could provide early warning sign for Parkinson's disease - NHS |
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06-21-2019, 09:03 PM | #2 | |||
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Grand Magnate
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Thanks jeffreyn; that looks very encouraging to me.
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06-30-2019, 01:10 AM | #3 | ||
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The AlzForum website has just published a fairly solid article covering this research (i.e. something that sits between the NHS article and the research paper itself).
Does Serotonin Pathology Foreshadow Parkinson’s Disease? | ALZFORUM |
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06-30-2019, 09:26 AM | #4 | ||
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So, dopamine deficiency is not the whole story with PD: serotonin plays a part too.
"The researchers found that in pre-symptomatic people with a hereditary risk of Parkinson's there was a loss of serotonin in several areas of the brain that are known to be affected in Parkinson's. Therefore this could be a change that happens in the early stages of Parkinson's." The thing I can't understand is why this research isn't translated into a simple serotonin based therapy. The same goes for the other neurotransmitters. John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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07-01-2019, 12:13 AM | #5 | ||
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Hi johnt,
When you say "a simple serotonin based therapy", do you mean something like giving PwPs the serotonin precursor 5-HTP (plus the equivalent of carbidopa?) to make up for the reduced level of serotonin? There may be research going on in this area, but I've not come across it (except for the Hinz protocol). |
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07-01-2019, 03:24 AM | #6 | |||
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Grand Magnate
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The aldehyde form of serotonin promotes formation of alpha-synuclein oligomers and serotonin blocks formation of amyloid from alpha-synuclein.
Whether these are clinically relevant remains to be seen. The serotonin aldehyde, 5-HIAL, oligomerizes alpha-synuclein. - PubMed - NCBI The neurotransmitter serotonin interrupts α-synuclein amyloid maturation. - PubMed - NCBI
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07-02-2019, 09:29 AM | #7 | ||
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So does this mean someone with PD or pre-PD should take an antidepressant like Prozac to increase their serotonin and decrease the formation of a-synuleins?
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07-02-2019, 02:53 PM | #8 | |||
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Grand Magnate
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SSRIs and SNRIs have been found to improve gait in people with PD though whether this is linked to serotonin:a-synuclein interactions is not clear.
Antidepressants for Depression, Apathy, and Gait Instability in Parkinson's Disease: A Multicenter Randomized Study. - PubMed - NCBI
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