Does anyone have any knowledge of or experience with citicoline?

aka CDPcholine has been a longtime favorite of Ron's and has a lot of research behind it. One word of caution though. In my own experience a little was good but too much was counterproductive as it seemed to trigger acetylcholine release which opposes dopamine. Fellow white rat juanhch reported a similar effect.

Hello pacem,
Yes, I have used citicholine (CDP choline), for years now. It is used in the medical profession to aid recovery from strokes, and helps brain metabolism. It has been reported to reduce the level of levodopa needed, which reduces side effects. I take a low dose of one 250mg tablet per day. Most trials have been done at around 1,000mg per day, but it is expensive. Citicoline reduces the permeability of the blood-brain barrier, which I believe helps parkies. I also take curcumin (which also reduces the permeability of the BBB). I have had PD for 16 years now, and still drive, only take 300mg levodopa per day, can go on demanding holidays, (Tahiti and Crete this year), and just finished laying 80 heavy concrete paving stones as a base for my garden shed. I am now 70 and take the dog a walk daily.
Of course, I can't assign this to any particular supplement, but I am worse when I stop citicoline altogether.
Hope this helps.

I have tried many mental boosters but citicoline is one of best for it. I took two capsules in a day (morning and afternoon) and I certainly notice a positive mental response. I also read Dr. Allen S. Josephs newsletter on it that give me the idea that why citicoline is so effective. I strongly recommended it!