Parkinson's Disease Tulip


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Old 11-01-2019, 07:30 PM #1
johnt johnt is offline
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Join Date: Apr 2009
Location: Stafford, UK
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johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
10 yr Member
Default Levodopa: 6 doses/day associated with less dyskinesia

A recent paper by Lin and Laurano [1] reports that a daily regimen based on 6 doses per day of levodopa is associated with a lower incidence of dyskinesia, compared with taking approximately the same total amount of levodopa in only 3 or 4 doses.

They also write that:
"To further reduce the fluctuation of levodopa in blood levels, entacapone [a catechol-O-methyltransferase (COMT) inhibitor] was also prescribed to most of the patients".

I've had no dyskinesia (diagnosed 14 years ago) on a regimen of 5 x 75 mg Stalevo, 1 x 8 mg ropinirole, 1 x 1 mg rasagiline.

I also dynamically dose: taking a pill when I begin to feel that the previous dose is about to start to decline in its effectiveness.

Reference:

[1] "Less Pulsatile Levodopa Therapy (6 Doses Daily) Is Associated with a Reduced Incidence of Dyskinesia"
Mark M. Lin, Robert Laureno
J Mov Disord > Volume 12(1); 2019
Less Pulsatile Levodopa Therapy (6 Doses Daily) Is Associated with a Reduced Incidence of Dyskinesia

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
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