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11-01-2019, 07:30 PM | #1 | ||
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A recent paper by Lin and Laurano [1] reports that a daily regimen based on 6 doses per day of levodopa is associated with a lower incidence of dyskinesia, compared with taking approximately the same total amount of levodopa in only 3 or 4 doses.
They also write that: "To further reduce the fluctuation of levodopa in blood levels, entacapone [a catechol-O-methyltransferase (COMT) inhibitor] was also prescribed to most of the patients". I've had no dyskinesia (diagnosed 14 years ago) on a regimen of 5 x 75 mg Stalevo, 1 x 8 mg ropinirole, 1 x 1 mg rasagiline. I also dynamically dose: taking a pill when I begin to feel that the previous dose is about to start to decline in its effectiveness. Reference: [1] "Less Pulsatile Levodopa Therapy (6 Doses Daily) Is Associated with a Reduced Incidence of Dyskinesia" Mark M. Lin, Robert Laureno J Mov Disord > Volume 12(1); 2019 Less Pulsatile Levodopa Therapy (6 Doses Daily) Is Associated with a Reduced Incidence of Dyskinesia John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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