Parkinson's Disease Tulip


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Old 12-20-2019, 10:16 AM #1
soccertese soccertese is offline
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soccertese soccertese is offline
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Default Sunovion Announces FDA Filing Acceptance of Resubmitted New Drug Application for Apom

Sunovion Announces FDA Filing Acceptance of Resubmitted New Drug Application for Apomorphine Sublingual Film


Sunovion Announces FDA Filing Acceptance of Resubmitted New Drug Application for Apomorphine Sublingual Film - MarketWatch


I was looking forward to this product release, who wouldn't want to be able to decrease one's OFF time by half or better?

when i read the results of the study and saw that 1/3 of the patients dropped out due to oropharyngeal side-effects i was less enthusiastic. but even if i got a little sick while taking this drug, it could provide a major benefit. i could go out to dinner and actually eat a full meal that would normally negate any l-d0pa taken in the next 2 hrs and just take this drug to bypass my digestive system.

just incredibly disappointing that the results were not all that great utilizing an agonist that has been in used for what, 50years? i think we deserve better. we need better agonists, are any being developed? i think the neupro patch was the last product using the "new" agonist rotigotine which also bypasses the digestive system. in 2004 i participated in a drug study testing a new agonist call sumanirole. the first phase compared sumanirole against requip, there might have been a placebo, can't remember. you dosed up to the most effective dose then stayed on that for awhile. then you found out whether you were getting requip or sumanirole. i got requip. as an aside, back then there were no generic reqUip, i took the brand name and i dosed up to 4mg and tolerated it quite well. since then i tried generic requip and felt like crap on one generic, spaced out on another generic so stopped taking since i couldn't afford the brand name. back to the sumanirole trial. in the 2nd phase of the study everyone got sumanirole and dosed up to an effective dose, then be on the drug for 6months. after 3 months the trial was cancelled. pfizer had bought out pharmacia which made sumanirole and i assume that since pfizer made requip they didn't want another agonist, just guessing here. i didn' t meet anyone else in the trial but heard that one person, a teacher, was able to go back to work taking sumanirole. certainly can't verify that. but what if this sumanirole is a lot better than requip or mirapex? i guess we will never know. i can say that when i participated in the trial my pd was not very advanced, i was still playing soccer, so i didn't notice much affect from requip or sumanirole, i will say i thought i had less "spaciness" with sumanirole. just have to wonder why aren't we seeing more agonist development. a company develops a suglingual apomorphine where a third of the patients can't tolerate the drug and they think the FDA will approve it and they probably will? i think we deserve better, especially when this new drug is likely going to be very expensive.
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johnt (12-22-2019)

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Old 12-20-2019, 12:00 PM #2
ashleyk ashleyk is offline
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Default Always disappointed

I to am disappointed in all these "new" drugs that really don't help all that much. When it comes down to it, sinemet is still the only drug that works for PD. All the others are just something the docs and big pharma throw at patients hoping something can work better. I think our only hope is stem cell therapy and who knows if and when that will be common. In the meantime, look for ways to tame inflammation, like curcumin and thiamin.

I recently came across a mega study claiming that there is a 3x risk of PD for people who had their appendix removed, like my wife.
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