Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 09-28-2020, 06:26 PM #1
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
Default Scientists Develop New System to Better Manage Medication Delivery

Scientists Develop New System to Better Manage Parkinson's Medications

the ideal system would be a dopamine agonist patch that works better than neupro or anything that bypasses the small intestine that didn't cost a fortune of the specially formulated ligquid carbidopa/levodopa. on 2nd thought, a cure would be better.
soccertese is offline   Reply With QuoteReply With Quote

advertisement
Old 09-28-2020, 07:51 PM #2
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
10 yr Member
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
10 yr Member
Default

If this technology were to work, it would be really useful. But ...

The ideal extended release levodopa pill would need its own dynamic guidance system to match the peaks and troughs of levodopa demand. Just slowing down the release would be inadequate, because it doesn't take into account the body's needs.

At least with immediate release levodopa you have the opportunity 3, 4, 5 or 6 times a day to synchronize levodopa demand with supply. This can be done either by changing the size of the next dose or by changing its time.

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
johnt is offline   Reply With QuoteReply With Quote
Old 09-29-2020, 01:34 PM #3
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
Default

i assume such a system would require adhoc 25/100, even DUOPA requires that. think of this probably will never be marketed drug like the requip you use, it provides a baseline so you never go off.

like the description that these caps float in your stomach and eventually disintegrate i assume.

wonder if rytary has same mechanism.
soccertese is offline   Reply With QuoteReply With Quote
Old 09-30-2020, 06:58 AM #4
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
10 yr Member
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
10 yr Member
Default

Yes. C/L has a half-life of about 90 minutes, whereas ropinirole has a half-life of about 6 hours.

Rytary is made up from different preparations of C/L: an immediate release bead and two extended. release types of beads. The idea being that their effects should combine to give a long lasting plateau. However, if something goes wrong and one of the beads is not absorbed properly there is no easy fix.
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
johnt is offline   Reply With QuoteReply With Quote
Reply

Tags
bypasses, cost, fortune, intestine, system

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
MedGenesis Partners with Pfizer to Develop GDNF Treatment and Delivery System for PD Tupelo3 Parkinson's Disease 11 10-26-2014 02:58 AM
New delivery system possibility Muireann Parkinson's Disease 4 04-18-2014 08:14 PM
ALS TDI and Asklepios to Develop New Therapeutic Delivery Options for Treating ALS. BobbyB ALS News & Research 0 01-20-2009 02:01 PM
MJFF awards 1mill, develop 'Trojan Horse' Delivery Technology to Treat PD Stitcher Parkinson's Disease 3 08-17-2008 01:26 PM


All times are GMT -5. The time now is 07:20 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.