"The real voyage of discovery consists,
not in seeking new landscapes, but in having new eyes."
Marcel Proust

Over the last 40 years, four courageous and compassionate neurologists have investigated the use of various substances to achieve a "miraculous" improvement in patients with many years of dignosticised disease and many years of levodopa-carbidopa plus other drugs (severe iatrogenic or treatment damage added to the original Parkinson's).

It is wonderful and fascinating to see how these substances are able to "revive" people whose bodies seem to have surrendered to oxidation, inflammation, loss of energy due to malfunctioning of the mitochondria, damage caused by treatments (iatrogenesis often worse than the original disease itself) and a long etcetera of possible causes.

I am reminded of a morning in 2010 when my father, for no known reason or cause, got up from his armchair as if he did not have Parkinson's, neither in the expression on his face, which looked as it had 25 years ago, radiant with happiness, nor in his movements, perfectly coordinated and full of energy. Only to "switch off" after a few minutes and return to his Parkinson's after 16 years of diagnosis and 10 years of levodopa-benserazide and pramipexole.

I am not going to give up because I know, I intuit (intuition is a shortcut to knowledge) that we have missed many important things waiting in digital databases such as Medline and in old books (Werbach, Pfeiffer, Wurtman, Pischinger, Reckeweg, Seignalet, Birkmayer, Knoll...).

1) BIRKMAYER - NADH (VITAMIN B3 COENZYME).

In the video we can see the neurologist Walther Birkmayer, pioneer of levodopa, after administering parenterally (intravenous infusion, but drop by drop) the vitamin B3 coenzyme NADH, essential in cellular respiration and in the energy of the mitochondria, the cell's energy factories. It also stimulates the natural production of dopamine.

NADH Parkinson Therapy - YouTube


2) PERLMUTTER - GLUTATHIONE.

In this one, the famous neurologist David Perlmutter accompanies several patients after administering parenteral glutathione and observing how they start to move in a surprising way. Although no such benefits were found in a later study (Hauser 2009), we now suspect that it could be because Perlmutter administered significant amounts of B vitamins to his patients before and during the tests (B1, B2, B3...).
Monti in 2019 has obtained similar results with the administration of NAC (N-acetylcysteine) orally and parenterally.

Glutathione Therapy for Parkinson's Part 1 from David Perlmutter, MD FACN - YouTube


3) COIMBRA - RIBOFLAVIN (VITAMIN B2).

One of the patients of the Brazilian neurologist Cicero Galli Coimbra who received in 2003 moderately high doses of riboflavin or B2 (30-30-30 mg daily) and at 6 months had achieved an average motor improvement of 44 to 71 %, with three of the 19 patients scoring 100 % according to the UPDRS scale.
The interview was conducted at three months, so the improvement continued after the video was made.

Jornal Nacional - Paciente recupera-se de Parkinson - YouTube


4) COSTANTINI - THIAMINE (VITAMIN B1).

And finally, at least since 2013 the use of vitamin B1 by the Italian neurologist Antonio Costantini, recently deceased (May 2020). Vitamin B1 is vital for numerous brain processes, such as the synthesis of neurotransmitters, antioxidant mechanisms, etc. It has been known since the 1960s that B1 deficiency leads to a deficit in dopamine synthesis (Linčt 1967) and its restoration to an increase (Yamashita 1993). Luong and Nguyen already established this in 2012. Smithline clarified many doubts in his study on how it works in the body in 2012: in high oral doses, blood concentrations similar to the intramuscular and intravenous routes are reached.
The therapy produced a significant improvement in motor function measured with the UPDRS scale between 31.3% and 77.3% (Costantini 2013, 2016).

Alberto was the first patient to see the immense improvement of intravenous benfotiamine therapy, a form of vitamin B1.

before starting:
Patient25 PD1 Alberto was the first patient in which we saw the impressive effects of thiamine in Pa - YouTube

2 weeks of therapy:
Patient25 PD2 The same patient after two weeks He had performed two vials im of 100 mg thiamine per - YouTube

two years of therapy:
https://www.youtube.com/watch?v=k6jyuCR0BMw

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For the first time in history, a patient can take control of his or her Parkinson's disease under the essential supervision of a neurologist and pharmacist. And to cope with the disease without the terrible side effects of only symptomatic drugs. It is now possible to prevent it, slow it down and control the symptoms (vitamins B1, B2, B3, B6, B9, B12, C, D3, magnesium, zinc, selenium, melatonin, resveratrol...).

The good news is that all substances are now available by liposomal and sublingual routes. In addition, there is the possibility with specific forms or powerful oral doses to bypass the body's mechanisms for limiting the absorption of certain substances (digestive tract, protective barrier of the brain).

1) Nicotidamide is better than niacin. Sublingual NADH.

2) N-acetylcysteine amide (NAC a), a precursor of cysteine (the hard-to-get part of glutathione) and able to cross the protective brain barrier without problems, as well as reaching neurons from astrocytes using glutamate transporters in the neuronal membrane (Aoyama 2011).

3) Oral doses of thiamine hydrochloride of 1.5 to 2 grams increase uptake to levels similar to the intramuscular and parenteral routes (Smithline 2012).

Two aspects are observed in the use of natural substances in high or very high doses (always under medical supervision):

- When a nutrient is used in very high doses, it must be accompanied in parallel by an increase in its cofactors. This is well known with the various B vitamins among themselves and with magnesium;

- The use of very high doses can bypass the body's mechanisms for limiting their oral assimilation. This also occurs when these high doses are repeated several times. For example, the 2000 mcg dose of B12 is effective even if there is no intrinsic factor in the stomach (Albadal 2005); the 1500 mg dose of thiamine hydroxyclohydrate reaches concentrations similar to the intramuscular route (Smithline 2012); until 2004 it was believed that the maximum concentration of vitamin C in the blood by the oral route was 80 micromoles per litre, and in 2004, studies by Polidori and Padayatti found that it could be three times as high; etc.).

And a question: why has no one tried using B1, B2, NADH and NAC amide in perhaps lower doses but adding or pooling the benefits of all the substances? Is it crazy to think that it would bring about a revolution in the world of Parkinson's?

(by Jesus Marquez Rivera. Parkinson here and now)

Hey Jesus,

What a fantastic article. Thanks for sharing. You have the ability to gather a great deal of information and make it seem straightforward and almost simple. And in a second language too.

I note all of the supplements you recommend B1, B2, NADH and NAC amide are available online even Professor Birkmayer's NADH.

Do you take any of these yourself as a preventative measure?

Birkmayer's NADH isn't cheap can you recommend a cheaper alternative?

Thanks again,
Atty

Hello, Atticus.
Thank you for your words.
I find it important that they are readily available and not expensive. NADH and NAC amide are expensive, especially the latter.
I prefer B1 and B2. B3 in the form of nicotidamide (similar in efficacy to NADH). And for glutathione, for now, alpha lipoic acid and milk thistle. Although everything must be adapted to each case by the specialist.
For prevention I take green tea with ginger and turmeric, brewer's yeast, magnesium chloride, vitamin C and omega 3 (EPA and DHA).
And a diet as close to the Mediterranean diet as possible.
Greetings. Thanks to you.