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03-17-2021, 12:06 PM | #1 | ||
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Press Releases - Yumanity Therapeutics BOSTON, March 09, 2021 (GLOBE NEWSWIRE) -- Yumanity Therapeutics (NASDAQ: YMTX), a clinical-stage biopharmaceutical company focused on the discovery and development of innovative, disease-modifying therapies for neurodegenerative diseases, today announced results of a study of its lead program, YTX-7739, that demonstrate pharmacological, physiological and behavioral pre-clinical proof of concept in a Parkinson’s disease (PD) mouse model. This oral presentation and two posters will be presented at the 15th Annual International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD™ 2021) Virtual Conference, March 9 to 14, 2021. “Evidence suggests that α-synuclein pathology is a strong risk factor for Parkinson’s disease,” said Dan Tardiff, Ph.D., interim Head of Research and Scientific Co-founder at Yumanity Therapeutics. “Our proprietary discovery platform led us to the target stearoyl-CoA desaturase (SCD), which when inhibited decreases the toxicity associated with pathogenic α-synuclein. Inhibition of SCD, an enzyme involved in lipid metabolism, has been shown to prevent α-synuclein pathology in multiple models, including patient-derived neurons, in vitro. The results from the current study demonstrate that YTX-7739 has a similar effect in a mouse model of Parkinson’s disease-related pathology. These results lend additional evidence to support our ongoing clinical program in Parkinson’s disease patients.” The research entitled, YTX-7739, A Clinical Stage Stearoyl-CoA Desaturase Inhibitor for Parkinson’s Disease Improves Behavioral and Pathological Features in an a-Synuclein Mouse Model, conducted in collaboration with the laboratories of Silke Nuber, Ph.D., and Dennis Selkoe, M.D., at Brigham & Women’s Hospital, will be presented at 12:30 p.m. [CET] on March 13 (live discussion March 13 from 5:30 to 6 p.m. CET) by Dr. Tardiff. The study evaluated YTX-7739 vs. control in the PD mouse model. The model was used to evaluate the effect of the drug on motor function as well as survival of neurons and associated biochemical features. The effects of the drug on lipid metabolism were also examined. The investigators found:
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"Thanks for this!" says: | Atticus (03-17-2021) |
03-25-2021, 09:13 AM | #2 | |||
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Thanks for this!
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