WE MOVE News

Subject: Continuous Levodopa for the Treatment of Parkinson Disease

Date: 9/4/2007

"When people with Parkinson disease (PD) first start taking levodopa/carbidopa, their symptoms typically improve and are usually evenly controlled over a period of time. However, as PD progresses, the symptoms "often become more difficult to control. The beneficial effects of a dose of levodopa/carbidopa usually don't last as long as they did during the earlier stages of the disease. Also, about half of people who take levodopa for at least five years develop a side effect called dyskinesia."

"Doctors think that if levodopa is given continuously, rather than now and then, the drug may control the symptoms of PD better and may not cause dyskinesia. How to deliver this constant dose of the medicine has been a challenge. A new treatment is being studied that constantly delivers levodopa/carbidopa in a gel form (Duodopa®) directly into a person's upper intestine."

"Who were the patients in this study and what did they do?"
"Nine people in Italy who were living with advanced PD took part in the study. They had motor fluctuations and dyskinesia that could not be controlled with levodopa taken by mouth and by dopamine agonists. None of these patients had dementia or hallucinations."

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...how well the old trick of dissolving the day's dose into a water bottle would do over a long time period?

And does anyone know if DMSO has been tried as a carrier for the skin patch approach?

i found this:

http://scienceblogs.com/retrospectac...roved_by_t.php
I've always been interested in how these skin patches work, specifically what they contain that transfers the enclosed drugs into the skin. After a quick search I found that one common ingredient in many transdermal patches is the chemical DMSO (if you are in a lab, you may have heard of it). DMSO (dimethyl sulfoxide) is a solvent and a by-product of the wood industry. In 1961 a Dr. Jacob noted that the chemical was able to penetrate the skin deeply without causing any damage. Later it was observed to be a superior solvent for pharmaceuticals, and capable of transporting chemicals across and into skin (for better or worse). Obviously you'd want to be careful with DMSO (for example, LSD is sometimes dissolved in DMSO), but these properties made it quite useful for introducing therapeutic drugs into the skin via the patch. The release of drug was constant and predictable, and patches were difficult to abuse (the strong painkiller fentanyl is sometimes delivered this way.)

and:

http://www.madsci.org/posts/archives...0244.Bc.r.html

There is a lot of research on this and other novel routes of drug delivery, by practically every major research drug company. Some chemicals can enhance delivery of drugs across the skin. One example is dimethyl sulfoxide (DMSO). It is (unfortunately) sold over the counter. It helps drugs gain entry basically by damaging the cell membrane to make it more permeable to other substances. This is generally not a very good idea. Not only does it damage the skin and other cells, sometimes permanently, but it also makes it difficult to control the amount of drug or other agent that passes through the membrane

hope this helps.

1- Quality. Do your homework

2- The real drawback, however, is the little blue and pink pills themselves. The DMSO will probably move all those nasty coloring agents and god knows what else straight into the system bypassing the GI tract.

Hello,

I have reviewed the information for DMSO on
and I was wondering if somebody has experienced this
medicine. Can we consider this as a common way of healing?

Thank you.