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10-31-2007, 07:46 AM | #1 | ||
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In Remembrance
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Does this imply that PD could be an immune system disorder once the initial insult occurs? Whatever that may be?
Or autoimmune? paula
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paula "Time is not neutral for those who have pd or for those who will get it." |
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10-31-2007, 08:28 AM | #2 | ||
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doesn't it mean that taking l-dopa will make us worse ?
I thought we had all agreed l-dopa does not make us worse, (thats "we" as in the royal "we") ! Have I missed the point ? Neil. |
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10-31-2007, 08:40 AM | #3 | ||
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In Remembrance
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I don't think anything has been proven......the more we discover, the more we realize we don't know. I know i have to take l dopa to function. If it also is harmful to me, wouldn't that be an immune problem?
REPEAT - in over my head. What, or who, is the royal we? My deformed little brain is overtaxed I fear. paula
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paula "Time is not neutral for those who have pd or for those who will get it." |
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10-31-2007, 08:56 AM | #4 | ||
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The royal "we" (Pluralis Majestatis) is the first-person plural pronoun when used by an important person to refer to himself or herself. Its best known usage is by a monarch such as a king, queen, or pope. It reflects the fact that when a monarch speaks he or she speaks both in his own name and in the name of his function, office or status.
Most famous quote is Queen Victoria's "we are not amused", (referring to her own lack of amusement). From climate change / Al Gore, to rugby, to PD as an (auto)immune condition, to English personal pronouns, we sure are covering a lot of ground with our typically incisive wit and drive Neil. |
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10-31-2007, 09:00 AM | #5 | ||
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In Remembrance
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Oh i see, like patronizing nurses in the hospital or nursing homes...how do we feel this morning? are we hungry?
only minus the royal. thank you Neil.
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paula "Time is not neutral for those who have pd or for those who will get it." |
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10-31-2007, 09:10 AM | #6 | ||
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No Paula that is called "the patronizing we", (no kidding), sits alongside "the editorial we", common in scientific literature, referring to a generic third person by "we" instead of the more common "one" or the informal "you":
e.g. "By adding three and five, we obtain eight". Something to discuss with your partner tonight !! Neil. |
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10-31-2007, 09:48 AM | #7 | |||
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In Remembrance
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Hey fellas, I am just reporting this, I haven't a clue whether it means we should not take l-dopa etc. If you think about it, healthy people have plenty of dopamine compared to our meagre supply. So why haven't they got PD and we haven't!!! (joke) Go figure.
It just seemed a relevant interesting paper. Dopamine is synthesised also in the body, and acts as a hormone. However, I guess the authors here are talking about processes in the brain, not in the body. The more I post, the more trouble I get into!!! LOL Ron |
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10-31-2007, 10:08 AM | #8 | |||
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Member aka Dianna Wood
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As it was explained to me, the dopamine pathways back up leaving no where for it to go so it begins to destroy itself. Levodopa can get through the blood brain barrier and substitute, though it be not as efficient as dopamine.
Which is why it is so hard to stay on an even keel. Too much levodopa and you add to the damage; not enough and you can't function. What role the other drugs play, I am not sure of. This information was first reported in the pathological study of patients who had a Parkin malformation. 1. Reviews in Neurological Diseases, Vol 1, No 3., 2004, author John J. Kelly, M.D., The George WashingtonUniversity Medical Center, Washington D.C. "Researchers from Switzerland, studied a more common, recessive form of inherated Parkinson's disease that typically strikes before the age of 40 and is linked to a mutation in the Parkin gene. The loss of enzyme activity resulting results in an accumlation of protein substrates, including alpha synuclein, in the cell. In these juvinile Parkinson's cases, lewey bodies do not generally present. In these forms of the disease involving buildup of alpha synuclein in the cell, would result in degeneration and death (of the cell.) Paula, this is what the GDNF factor was about. By combining a virus and Parkin and delivering it into the cells, protected the cells from neurotoxicity. 2. "Protecting microtubule "highways" may lead to novel therapies", Medical Neurology, 12.6.2004 states that Parkinson's disease may be caused by a double whammy; mutated Parkin genes combined with the highly toxic chemical rotenene, results in a cascade of highly toxic free radicals, the destruction of microtubules that transport dopamine to the brain's movement center, and eventioal death of the dopamine producing neuron. 3. "Progression of nigrostriatal dysfunction in a parkin kindred: an [FDOPA PET and clinical study. MRC Clinical Sciences Centre, London, England. Received November 21, 2001, Revised March 27, 2002, Accepted April 24, 2002. "Neuropathology of Parkin cases is limited but, in cases that have been reported, there was a generalized loss of dopaminergic neurones in the substantia nigia pairs compacta without Lewy body inclusions. ...subclinical nigrostriatal dysfunction has been demonstrated in carriers of a single mutent parkin allele (Hilker et al, 3001). RESILTS <eam age pf pmset su,[tp,s was 29 uears (ramge 28 - 32 years). All affected siblings ha a striking response to L-dopa therapy, with levodopa-related dyskinesias after a mean interval of 2.4 years. Estimated mean clinical disease was 26 years (range 19 - 32 years) at the time of the second scan. The clinical presentation of the patients was comparable with that of juvenile-onset parkinsonism; however, currently their phenotype was indistingshable from IPD, with a common feature of severe resting leg tremor. 4. "Parkin Stabilizes Microtubiles Through Strong, Binding Mediated by t=Three Independent Domains."" The American Society for Biochemistry and Molecular Biology. From Department of Physiology and Biophysics and Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 5. Parkin counteracts symptoms in a Drosohila model of Parkinson's disease. Annika FM Heywood and Brian E. Staveley, Univerisity of Newfoundland, Department of Biology, St. John's, Newfoundland and Labrador, Canada. Publlish 16 April, 2004. BMC Neuroscience. Conclusions: Our experiments demenstrate that the directed expression of the parkin gene counteracts the PD-like symptoms." 6. Striatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism, Brain Vol 127 No 6, 2004. Tired of typing. Going back to bed. I have followed this trail of infor for many years. Sincerely, Vicky |
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10-31-2007, 10:28 AM | #9 | ||
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Junior Member
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Lewy bodies are found in cells that don't produce dopamine.
See: Lewy body dementia. |
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10-31-2007, 11:18 AM | #10 | ||
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Member
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can you expand on this for the less scientific (or intuitive) amongst us (i.e. me).
Thank you, Neil. |
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