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10-31-2007, 08:00 PM | #11 | ||
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When I went to school and when I first started to teach, classes were arranged according to level of achievement. That is no longer politically correct. However, I can tell you folks above would have been in the top group. When I read some of these scientific tomes, I get glassy eyed and dazed. I do not have the background to understand the content of your posts. Somebody should speak for those of who are not as clued in to the science of what you are saying. You have heard of legal-eze language. I need deciphering of the scientific-eze language, or in other words, "Say what?"
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10-31-2007, 08:42 PM | #12 | |||
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In Remembrance
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I, too, was once mortal....
But seriously, there are only two reasons to tackle the learning curve here. One is the sincere and not totally baseless hope of finding something that has been overlooked. The second is the feeling that one has some control over one's life. A writer once said ( I think it was Rhetta Ghrimley Johnson ) "I come from a family that believed that with enough library time any problem could be solved." Were that it was always true, but I gotta try. The single greatest aid to understanding this language that I have found is a simple little program free for the download at www.answers.com called 1-Click Answers. Install it and anytime you run across a word you don't know just Alt-click it. A little popup screen appears with a short definition and then goes away. It is one of the most elegant little pieces of software I have ever seen.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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11-01-2007, 01:25 AM | #13 | ||
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Those molecules that readily give up an electron from a hydrogen ion and are small enough or nimble enough to invade complex 1 or complex 4 are the substances we need to watch. The resulting yields in the equation lack the production of water as a by-poduct and result in dehydration and eventual acidosis and apoptosis or necrosis. Once the molecule is utilized by the mitochondria, it is tagged as being "human" and is no longer considered an aliien by the immune system and is, essentially, granted a pass to move on to another cell.
That's the way I see it, anyway. See electron donors and electron acceptors---hydrogen donors and hydrogen acceptors and cross reference what you find with known Parkinson's initiators. michael b. |
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11-01-2007, 01:46 AM | #14 | ||
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In Remembrance
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Welcome Michael, I was hoping this conversation would get your attention.
I'm fascinated that i can follow it even some. We are fortunate to have such. as Rick might label them, 'superpower minds' [which we all know from watching Spiderman, are not mortal] on the forum. paula
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paula "Time is not neutral for those who have pd or for those who will get it." |
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11-01-2007, 01:49 AM | #15 | ||
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Quote:
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11-01-2007, 01:53 AM | #16 | ||
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Oops, I didn't know anybody was watching. How are you?
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11-01-2007, 07:59 AM | #17 | ||
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Thanks for making it so clear!
Ann |
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11-01-2007, 09:43 AM | #18 | ||
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http://www.brooklyn.cuny.edu/bc/ahp/...ochondria.html
Here are the contents of that website. Quote:
michael b. |
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11-01-2007, 11:24 AM | #19 | ||
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Yappiest Elder Member
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Quote:
at the top of the NeuroTalk page there is also direct links to PubMed, Drugs and a Medical Dictionary. makes it easy to look up something without leaving the post you were reading. i hope this helps. also the link rick gave is great.
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11-01-2007, 10:02 PM | #20 | |||
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I'm in a rush to go home, but want to leave you with this link:
Inhibition of brain mitochondrial respiration by dopamine and its metabolites: implications for Parkinson's disease and catecholamine-associated diseases "In summary, mitochondrial respiration can be inhibited by DA and its metabolites by four distinct MAO-dependent and independent mechanisms." Journal of Neurochemistry Volume 91 Issue 4 Page 788-795, November 2004 Martin R. Gluck, Gail D. Zeevalk (2004) http://www.blackwell-synergy.com/doi....x?cookieSet=1 Let me know if you don't have access to the article. I can email it if necessary. |
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