I was on 21 25/100 pills per day in addition to 3 50/200. My paranoia was so bad along with on and off time every hour. I was dx in 2005 although symptoms were visable in 1999. The worse my symptoms got the dosages were increased. I went from normal functioning to off time unable to walk in 5 minutes. Unpredictable to make my life totally unmanageable. Sometimes I was in a wheel chair sometimes not. DBS was my only option. The past 2 months I have only had on time and have not needed the wheel chair. I go to the gym every day for an hour. My stimulator has been adjusted twice and my medication reduced to 14 25/100 and 2 50/200. I have my third programming in 3 weeks. The plan is to reduce my medication again. I have been totally "on" and hope that it lasts. I would recommend DBS to anyone who has problems like mine . There is a book by authors Farris and Giroux a patient guide to DBS
available from Amazon. The surgery was no big deal and all my fears did not happen. It has given me my life back. I hope it lasts . It does not stop progression but the neuro can program as needed.