| FAQ/Help |
| Calendar |
| Search |
| Today's Posts |
12-01-2007, 03:20 PM
|
#1 | |||
|
||||
|
Member
|
One thing that bothers me a lot is pain in the area around my eyeballs. It can particularly hurt if I rapidly turn my eyes to either side. Carbidopa/levodopa relieves the pain. My eye pain is actually one of the first indicators that I need to take another dose.
I haven't heard much about this sort of pain in association with PD. I was wondering if anyone else has similar symptoms. Karl |
|||
|
 Reply With Quote
|
|
12-01-2007, 09:46 PM
|
#2 | |||
|
||||
|
Member aka Dianna Wood
|
Were you aware that one of the primary locations for dopamine in the body is the fluid behind the cornea. The Drosophila gene expresses Parkin which suppresses a-synuclein protein production. If, like myself, you have a Parkin mutation, and do not have the Parkin to suppress the alphasynuclein which causes degeneration of the ommatidial array, the external structure of the eye is unaffected.
Retinal damage can be observed by examining an optical effect termed the pseudopupil which is lost. See research article "Parkin Counteracts Sym[toms in Drosophila model of Parkinson's diseaseBMC Veirpscoemce. Volume 5, published 16 April, 2004. I plan to take my copy of this article to my next optometry appointment. Sincerely, Vicky |
|||
|
|
Reply With Quote
|
|
12-02-2007, 03:11 AM
|
#3 | |||
|
||||
|
Member
|
Vicky,
Thanks for the information! I didn't know anything about the information you provided. It's going to take me a while to understand. I might take this to my next doctor's appointment. I did know that dopamine is used in many places in the body and I also knew that the eyes are one of those places. My understanding is that dopamine production occurs in, at, or near the eyes, which is in addition to the dopamine production in the substantia nigra. The possibility that I am losing dopamine production in more than one location worries me. This seems to go beyond the normal definition of PD. I do know this much: The eye pain I'm experiencing is becoming one of the worst problems I have. Yes, the carbidopa/levodopa helps, but the rate of change for the worse seems to be most pronounced at my eyes. Karl |
|||
|
|
Reply With Quote
|
|
12-02-2007, 08:41 AM
|
#4 | |||
|
||||
|
In Remembrance
|
Our eyes are girdled with bands of muscles. Like our diaphragms, they can stiffen as we cycle through our medications.
__________________
Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
|||
|
|
Reply With Quote
|
| Reply |
|
|
Similar Threads
|
||||
| Thread | Forum | |||
| Need Evidence That Pain Meds WILL work for MS Pain | Multiple Sclerosis | |||
| Pain Numeric Rating Scale May Be Only Moderately Accurate for Pain Screening CME/CE | Chronic Pain | |||
| Pain Numeric Rating Scale May Be Only Moderately Accurate for Pain Screening CME/CE | Spinal Disorders & Back Pain | |||
| Gene Variation affects pain sensitivity and risk of chronic pain - NIH press release | Reflex Sympathetic Dystrophy (RSD and CRPS) | |||
| Gene Variation affects pain sensitivity and risk of chronic pain - NIH press release | Chronic Pain | |||
Pain Around the Eyeballs
Linear Mode
