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12-14-2007, 02:21 PM | #1 | |||
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J Neurochem. 2007 Oct 31 [Epub ahead of print] Links
Therapeutic effects of Coenzyme Q(10) (CoQ(10)) and reduced CoQ(10) in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine model of Parkinsonism.Cleren C, Yang L, Lorenzo B, Calingasan NY, Schomer A, Sireci A, Wille EJ, Beal MF. Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY, USA. Coenzyme Q(10) (CoQ(10)) is a promising agent for neuroprotection in neurodegenerative diseases. We tested the effects of various doses of two formulations of CoQ(10) in food, and found that administration in the diet resulted in significant protection against loss of dopamine, which was accompanied by a marked increase in plasma concentrations of CoQ(10). We further investigated the neuroprotective effects of CoQ(10), reduced CoQ(10) (ubiquinol), and CoQ(10) emulsions in the (MPTP) model of Parkinson's disease (PD). We found neuroprotection against MPTP induced loss of dopamine using both CoQ(10), and reduced CoQ(10), which produced the largest increases in plasma concentrations. Lastly, we administered CoQ(10) in the diet to test its effects in a chronic MPTP model induced by administration of MPTP by Alzet pump for one month. We found neuroprotective effects against dopamine depletion, loss of tyrosine hydroxylase neurons and induction of alpha-synuclein inclusions in the substantia nigra pars compacta. The finding that CoQ(10) is effective in a chronic dosing model of MPTP toxicity, is of particular interest, since this may be more relevant to PD. These results provide further evidence that administration of CoQ(10) is a promising therapeutic strategy for the treatment of PD. PMID: 17973981 [PubMed - as supplied by publisher]
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