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01-06-2008, 02:57 PM | #1 | |||
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Free Radic Biol Med. 2007 Dec 4 [Epub ahead of print]
Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: Therapeutic implications for Parkinson's disease explained via in silico studies. Jagatha B, Mythri RB, Vali S, Bharath MM. Department of Neurochemistry, National Institute of Mental Health and Neurosciences, 2900, Hosur Road Bangalore 560029, Karnataka, India. Oxidative stress has been implicated in the degeneration of dopaminergic neurons in the substantia nigra (SN) of Parkinson's disease (PD) patients. An important biochemical feature of presymptomatic PD is a significant depletion of the thiol antioxidant glutathione (GSH) in these neurons resulting in oxidative stress, mitochondrial dysfunction, and ultimately cell death. We have earlier demonstrated that curcumin, a natural polyphenol obtained from turmeric, protects against peroxynitrite-mediated mitochondrial dysfunction both in vitro and in vivo. Here we report that treatment of dopaminergic neuronal cells and mice with curcumin restores depletion of GSH levels, protects against protein oxidation, and preserves mitochondrial complex I activity which normally is impaired due to GSH loss. Using systems biology and dynamic modeling we have explained the mechanism of curcumin action in a model of mitochondrial dysfunction linked to GSH metabolism that corroborates the major findings of our experimental work. These data suggest that curcumin has potential therapeutic values for neurodegenerative diseases involving GSH depletion-mediated oxidative stress. PMID: 18166164 [PubMed - as supplied by publisher]
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In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices. ~ Jean-Martin Charcot The future is already here — it's just not very evenly distributed. William Gibson |
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"Thanks for this!" says: | imark3000 (01-08-2008) |
01-07-2008, 07:06 PM | #2 | |||
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Circumin may raise acetylcholine. I take artane to reduce my acetylcholine, so I'll use circumin if I start to take drugs that increase my L-Dopa.
It's the ratio of dopamine to acetylcholine that's important. If too much acetylcholine vs less dopamine, you get symptoms. Old thread: http://neurotalk.psychcentral.com/ar...hp/t-2913.html |
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01-07-2008, 09:54 PM | #3 | |||
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In Remembrance
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If there is one wonder drug in the non-pharma world, it is this one.
It is a great anti-inflammatory in addition to the paper above. There is a paper on Medline where Chinese research showed that it straightened out the stress axis. And it kills h. pylori. Those last two points bring warnings- 1) If you are high strung you may need a certain level of stress hormones to avoid depression. 2) Kill off h pylori when you are constipated and you may poison yourself. I have two "funny" fingers on my right hand to remind me of that. Otherwise...
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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01-08-2008, 02:10 AM | #4 | |||
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In Remembrance
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Yes, and don't forget it reduces BBB permeability!!
I have been taking it now since 2002. Ron PS Thanks Olsen for finding this paper |
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"Thanks for this!" says: | imark3000 (01-08-2008) |
01-08-2008, 07:08 AM | #5 | ||
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Turmeric is avialable here (Jordan), cheap and can be tasty. Any idea how much Turmeric daily would be good to sypply enough curcumin? 1/2/one tea spoon???
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Imad Born in 1943. Diagnosed with PD in 2006. |
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01-09-2008, 02:04 AM | #6 | |||
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In Remembrance
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IMark,
The curcumin content of turmeric is quite low, around 3%. So 1 gram of turmeric contains 0.03g or 30 mg of curcumin. So a teaspoon would give you about 100mg curcumin. Curcumin has been shown to be safe up to 8 gms, but of course don't take that much. You can stir turmeric powder into a glass of water to take it. I take four 500mg curcumin capsules per day, bought from iHerb. Best wishes Ron |
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"Thanks for this!" says: | imark3000 (01-09-2008) |
08-12-2008, 06:28 PM | #7 | ||
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John takes 1 500 mg a day of curcumin but am now going to suggest he ups the dose.Compared to other supplements he takes it is cheap. Although the supplements are for the long term benefits, I certainly notice he is worse if he forgets them for a few days.
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08-12-2008, 06:32 PM | #8 | ||
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Are you saying that the Curcumin has the potential to make the tremor worse?
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