You had me worried on account of the not so much talked about relationship between PD (dopamine) and sex . I got some relief from reading the whole link .... I understand that dopamine is connected with impulsive sex while Oxytocin enhanse stable relationships ,, so wpd's sexual functions should remain ok even with depleted dopamine !

Hi Randy,

This is very similar to my very first dose of dopamine. Up to that point, I was very stiff. My teeth were clenching to a point I was breaking molars, my left hand had become a fist (bruises in the palm from fingernails), and my legs were so tight I couldn't stand up straight. My arms were so sore through the shoulder and biceps I always felt like I was punched or walked into a doorway.

Well after that very first pill, which gave me a little nausea at first, I felt like a different person. All of the pain like I had before including the dystonia went away! I've been on it since with great results up until recently where my nurse and others think I'm ready for a change in dosage or medications.

John

i've read not everyone on sinemet gets dyskenesia. Does anybody know what percentage of pwp get dyskenesia.

In many ways its irrelevant to me, because my quality of life has improved with that cheap looking, dusty yellow tablet.

rand

Hi Randy and all other interested parties

I am in my 14th year as a PwP having been diagnosed at age 37 years. I was diagnosed back in the days when Sinemet was really prescribed straight away. As you mentioned Randy the effect when you first take is euphoric and I called it the miracle drug. I remember so clearly asking my neurologist how long this would last and was told 'you should have about 10 good years before things get rough'. He was about five years short. Permax a dopamine agonist (pergolide) and Comtess( Comtan) were added to my regimen and I developed very severe dyskinesia which persisted unabated for several years before I found a very kind PD nurse who took time out to finely tune my meds by weaning me off sinemet and Requip and onto Stalevo, Apomorphine, Rotigotine transdermal skin patches, and Amantadine. The latter dampens down dyskinesia

The tall and short of it is that each case (person) is unique. Although there are some general characteristics common to everyone there are differences. For example each person will react differently; some will experience nausea, other severe dyskinesia, others a very mild reaction. PD is a very personal illness that is its signature. Just be aware that there are now many new and wonderful drugs akin to Sinemet that can relieve your symptoms should it begin to wear off or you develop dyskinesia.

All the best in your walk with this wretched illness

Martin

Sorry to disillusion you but mucana is a drug in the same way that digitalus(spelling?)from foxgloves is a drug for the heart.It is natural and not synthetic but it is a drug. It may be better than sinemet because it has other chemicals within it.I do not know, but do not fool yourself that you are not on a drug

PD seems to be very unique to the individual in addition to the fact the reporting of symptoms is always subjective. Mucuna taken alone in relatively small quantities goes along with the philosophy of symptoms management with minimum L-dopa input to the brain.