this I have taken since 2000 and I have very little dyskinesia


Withania somnifera, also known as ashwagandha, was found in a rodent study to be helpful for tardive dyskinesia symptoms although it is not known whether ashwagandha would be helpul in dyskinesia due to L-DOPA induce dyskinesia.

http://www.raysahelian.com/parkinson.html

I think it's also called Indian ginseng.

How it may work:

Journal of Medicinal Food
Effect of Withania somnifera Root Extract on Haloperidol-Induced Orofacial Dyskinesia: Possible Mechanisms of Action
To cite this paper:
Pattipati S. Naidu, Amanpreet Singh, Shrinivas K. Kulkarni. Journal of Medicinal Food. July 1, 2003, 6(2): 107-114. doi:10.1089/109662003322233503.


Pattipati S. Naidu, PhD
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
Amanpreet Singh, PhD
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
Shrinivas K. Kulkarni, PhD
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India

We investigated the role of oxidative stress in the pathophysiology of haloperidol (HP)-induced orofacial dyskinesia and evaluated the beneficial effect of Withania somnifera (Ws) root extract in the amelioration of HP-induced vacuous chewing movements (VCMs) and tongue protrusions in the rat model for TD. Rats were treated for 21 days with intraperitoneal HP (1 mg/kg); on day 22, VCMs and tongue protrusions were counted during a 5-minute observation period. HP-treated rats significantly developed these extrapyramidal symptoms, but coadministration of Ws root extract (100-300 mg/kg) dose-dependently reduced them.

Biochemical analysis revealed that chronic HP treatment significantly increased lipid peroxidation and decreased forebrain levels of glutathione and the antioxidant defense enzymes, superoxide dismutase (SOD) and catalase.

Coadministration of Ws extract significantly reduced the lipid peroxidation and significantly reversed the decrease in forebrain SOD and catalase levels but had no significant effect on the HP-induced decrease in forebrain glutathione levels. These findings strongly suggest that oxidative stress plays a significant role in HP-induced orofacial dyskinesia and that Ws could be effective in preventing neuroleptic-induced extrapyramidal side effects.

Prog Neuropsychopharmacol Biol Psychiatry. 2007 Sep 21 [Epub ahead of print]Click here to read Links
Withania somnifera: An Indian ginseng.
Kulkarni SK, Dhir A.

Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh — 160 014, India.

Withania somnifera, popularly known as Ashwagandha is widely considered as the Indian ginseng. In Ayurveda, it is classified as a rasayana (rejuvenation) and expected to promote physical and mental health, rejuvenate the body in debilitated conditions and increase longevity.

Having wide range of activity, it is used to treat almost all disorders that affect the human health. The present review discusses the pharmacological basis of the use of W. somnifera in various central nervous system (CNS) disorders, particularly its indication in epilepsy, stress and neurodegenerative diseases such as Parkinson's and Alzheimer's disorders, tardive dyskinesia, cerebral ischemia, and even in the management of drug addiction.

PMID: 17959291 [PubMed - as supplied by publisher]

what a great researcher you are, my dear zflower!