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02-03-2008, 11:37 PM
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In Remembrance
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because of the article containing different alternatives to help PD - before trying any of these alternative methods -consult with your doctors.. A MUST!
Valerian root is dangerous for many already depressed and on medications! this article is from www.uspharmacist.com http://www.uspharmacist.com/oldforma...&article_id=83 Side Effects and Toxicity Several reports of toxic effects of the valepotriates have surfaced since the early 1980s. Because the valepotriates possess an epoxide structure, they demonstrate alkylating activity in cell culture. Valepotriates were shown to be cytotoxic to tumor cells, mouse early hematopoietic cells, and human T-lymphocytes.21,22 They also inhibited the incorporation of [3H]thymidine into DNA of Ehrlich ascites carcinoma cells.23 Alkylating agents show a good correlation between alkylating potency and mutagenic potency in the Ames test.24 Purified valepotriates and their decomposition products—baldrinal and homobaldrinal—were investigated for their genotoxic activity in the Salmonella/microsome test (Ames test) and the SOS-chrom test.25 The valepotriates developed mutagenic activity in these test systems only after being activated by esterases, whereas baldrinal and homobaldrinal showed direct mutagenic effects in both tests. When evaluating the potential in vivo danger of these cytotoxic effects, it must be noted that valepotriates are lipophilic compounds and are thus present only in very small quantities—if at all—in most standard aqueous extracts of valerian roots. They are also unstable in most extracts and are poorly absorbed after oral administration. Therefore, concentrations achieved in vitro would unlikely occur in vivo. In studies of CNS depressant activity of the purified sesquiterpene valerenic acid in mice, extremely high injected doses (150?00 mg/kg) resulted in muscle spasms and strong convulsions.11 Despite these toxicological findings, there have been no clearly identified toxicities reported in humans.26 However, reports of headaches, excitability, and cardiac disturbances have been noted in various clinical trials.26 Because of its potential effects on uterine contraction, valerian’s use during pregnancy could be problematic. Importantly, valerian extracts have not proven to act synergistically with alcohol as have the benzodiazepines. The interaction of valerian with other CNS depressants such as opiates, barbiturates, and benzodiazepines, is unclear. Valerian root WARNING- can be very dangerous for those on any medication link - http://www.uspharmacist.com/oldforma...&article_id=83 another link of warnings about valerian root http://www.herbmed.org/Herbs/Herb133...tegory5Herb133
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with much love, lou_lou . . by . , on Flickr pd documentary - part 2 and 3 . . Resolve to be tender with the young, compassionate with the aged, sympathetic with the striving, and tolerant with the weak and the wrong. Sometime in your life you will have been all of these. Last edited by lou_lou; 02-04-2008 at 12:06 AM. |
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| "Thanks for this!" says: | imark3000 (02-04-2008), soccertese (09-04-2010) |
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Valerian root extreme caution - must read
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