Neurology. 2006 Oct 10;67(7):1262-4. Related Articles, Links


Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial.

Bender A, Koch W, Elstner M, Schombacher Y, Bender J, Moeschl M, Gekeler F, Muller-Myhsok B, Gasser T, Tatsch K, Klopstock T.

Department of Neurology, Klinikum Grosshadern, Klinikum Grosshadern, University of Munich, Germany.

Mitochondrial dysfunction plays a major role in the pathogenesis of Parkinson disease (PD). Creatine (Cr) is an ergogenic compound that exerts neuroprotective effects in animal models of PD. We conducted a 2-year placebo-controlled randomized clinical trial on the effect of Cr in 60 patients with PD. Cr improved patient mood and led to a smaller dose increase of dopaminergic therapy but had no effect on overall Unified Parkinson's Disease Rating Scale scores or dopamine transporter SPECT.

PMID: 17030762 [PubMed - in process]

Okay--no effect on UPDRS, but elevated mood, and smaller dose increase of dopaminergic therapy. anyone here taking creatine? madelyn