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04-04-2008, 07:12 AM | #1 | |||
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In Remembrance
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We see a number of references which show a cup of coffee seems to slow the incidence of PD.
A new report explains why, and yet again, it is due to closing the permeability of the blood-brain barrier (BBB). Interesting is the fact that cholesterol disrupts the BBB, I wonder how many of us suffer high cholesterol, (I don't). http://www.jneuroinflammation.com/content/5/1/12 High levels of serum cholesterol and disruptions of the blood brain barrier (BBB) have all been implicated as underlying mechanisms in the pathogenesis of Alzheimer's disease. Results from studies conducted in animals and humans suggest that caffeine might be protective against Alzheimer's disease but by poorly understood mechanisms. Using rabbits fed a cholesterol-enriched diet, we tested our hypothesis that chronic ingestion of caffeine protects against high cholesterol diet-induced disruptions of the BBB. New Zealand rabbits were fed a 2% cholesterol-enriched diet, and 3 mg caffeine was administered daily in drinking water for 12 weeks. Total cholesterol and caffeine concentrations from blood were measured. Olfactory bulbs (and for some studies hippocampus and cerebral cortex as well) were evaluated for BBB leakage, BBB tight junction protein expression levels, activation of astrocytes, and microglia density using histological, immunostaining and immunoblotting techniques. We found that caffeine blocked high cholesterol diet-induced increases in extravasation of IgG and fibrinogen, increases in leakage of Evan's blue dye, decreases in levels of the tight junction proteins occludin and ZO-1, increases in astrocytes activation and microglia density where IgG extravasation was present. Chronic ingestion of caffeine protects against high cholesterol diet-induced increases in disruptions of the BBB, and caffeine and drugs similar to caffeine might be useful in the treatment of Alzheimer's disease. Most of the recent information on the BBB is in thread http://neurotalk.psychcentral.com/thread12139.html Ron
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Diagnosed Nov 1991. Born 1936 |
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04-04-2008, 07:30 PM | #2 | |||
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I don't drink coffee, but I get my caffeine from diet coke or pepsi. Sometimes I just need a coke sooo bad. I try to limit it to 3-4 cans a week. But no question it fills some sort of need. J
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I would never die for my beliefs because I might be wrong. Bertrand Russell |
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04-05-2008, 03:17 AM | #3 | |||
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In Remembrance
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....I wondered how the diet soda affects your symptoms?
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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