dear brother cs,
I would like to thank you for explainig the concepts of the biochemistry
involved in this article - you are so excellent at making hard things
easy to understand - bravo!


luv, &

Inosine makes a perfectly good target.

The issue is whether dietary inosine makes it into the brain - the most successful finding to date is with regards to intracerebrally administered inosine which showed it had astonishing benefits on brain rewiring.

""The significance of this study is that it shows the largest amount of rewiring after a stroke ever found in an animal model," Dr. Benowitz says. "Of course, its relevance to humans now needs to be demonstrated.""

I am one of several forum members taking DM. I use it in the same way originally recommended for naltrexone by Dr. Bihari. The work referenced by Ashleyk by Dr. Hong and the availability of DM in pediatric cough medicines without a prescription is the basis for my substituting it for LDN.
I have been taking DM (Pedia Care Long Acting; one-half to one-third tsp. every night before bed) for six years now. I was diagnosed by the head of a university neurology department in 2001, and my symptoms have progressed very little in that time. My only other meds are generic regular sinemet, 25/ 100mg and 2X generic sinemet cr 50/200, plus 100mg amantadine.
My neuro calls me his "PD poster boy".