Parkinson's Disease Tulip


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Old 05-22-2008, 09:58 AM #1
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Default Does L-dopa relieve PD tremor?

In my case it doesn't seem to help. The following paper also confirms this.
What is your experience?

http://www.springerlink.com/content/w320115652210q61/
Alessandro Agnoli1, Massimo Casacchia1, Stefano Ruggieri1, Federico Volante1 and Neri Accornero1

(1) 1a Clinica delle Malattie Nervose e Mentali, State University of Rome, Rome, Italy

Received: 27 March 1972
http://www.springerlink.com/content/w320115652210q61/
Summary Tremor is among the parkinsonian symptoms one of the most difficult to control. Even the treatment by l-DOPA does not give satisfactory results. According to recent biochemical hypothesis, a loss of functional balance of cerebral serotonin and histamine seems to be responsible for the symptom. The results obtained by the administration of antihistaminic, antiserotoninic, antiaminic and acetylcholinic drugs were quantitatively compared by using a piezoelectric accelerometer. The antihistaminic drug is found to be very active but unfavourable side effects are present, while the antiaminic drug is not less active, with the advantage of being free of such effects.
Key words Parkinson-Tremor - Tremor in Parkinson - Antiaminic Drugs - l-DOPA
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Old 05-22-2008, 12:10 PM #2
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Default Not really, unfortunately

But know what helps us the most? The nicotine patch and, for a non-drug treatment, snuggling and cuddling. I have no idea why, but it REALLY helps, every time. Maybe it's nature's way of telling us we need to quit spending so much time over trivial things and spend more time hunting and gathering!
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Old 05-22-2008, 02:57 PM #3
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Default Hi Imark ...

Ldopa helps my tremor and other motor movements such as repetitive movements and initiating movement.

Apparently young onset respond well to Ldopa (allegedly), and I thought you were young onset. Shows what a weird diseae we have.

Have you tried dop ags for tremor ?

Neil.
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Old 05-22-2008, 07:15 PM #4
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Default

I'm young onset (dx at age 41 nine years ago). L-dopa does not help my resting tremor; I take amantadine for that; very effective for me, but does not work for everyone. In my case, L-dopa works for general fluidity of movement.
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Old 05-22-2008, 08:43 PM #5
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Default doesn't help this young onset either

Dx at age 43 two years ago.

Quote:
Originally Posted by indigogo View Post
I'm young onset (dx at age 41 nine years ago). L-dopa does not help my resting tremor; I take amantadine for that; very effective for me, but does not work for everyone. In my case, L-dopa works for general fluidity of movement.
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Old 05-22-2008, 10:46 PM #6
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Default Agonists help mine

My neuros have said that tremor is the most intractable of the Parkinson's symptoms, and one with a great deal of variability from case to case. For some people Sinemet works, for others an agonist, for others nothing works but DBS. I am not tremor dominant, but do have some tremor in my arm and leg on one side that was difficult to hold down before I got medicated, and now shows up on both sides off med. Permax, an agonist, did nothing for it. Sinemet alone covered some of it. Mirapex very nearly stopped it for several years, but the side effects finally overcame my wish for stillness. I've been taking Requip for a couple of years now, and it covers the tremor pretty well. After I had surgery on my hip, my internist had me taking extra Requip for the shakes I would get at bedtime, and it was effective for that.

Dx at 53 in 1999.

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Old 05-23-2008, 03:10 PM #7
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Default thanks every one for the info

Quote:
Originally Posted by aftermathman View Post
Ldopa helps my tremor and other motor movements such as repetitive movements and initiating movement.

Apparently young onset respond well to Ldopa (allegedly), and I thought you were young onset. Shows what a weird diseae we have.

Have you tried dop ags for tremor ?

Neil.
I am 64. diagnosed 2 years ago. my most prominent symptom has been right arm weakness and tremor. so i have to use left hand most of the time.
i take many supplements and 2 tea spoons of mucuna daily and no pd medication. my tremor is not severe but increased recently a bit. i doubled the mucuna dose with no effect.
i am looking up (hoping) for natural means, diet or supplement to help
Neil : what is dop ags?
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Old 05-24-2008, 02:37 PM #8
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Default Hi Imark ...

must be your youthful outlook that made me think you were a young onset (40 years old or younger)

Dop Ags are my shorthand for Dopamine Agonists, as a young onset myself I was started on dop ags alone (no ldopa), and they did the trick for a couple of years. Obviously as your responses to this point have shown, not everyone will have had the same experience, then there are the side effects, either way I wouldn't change my treatment to this point.

Take care,
Neil.
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Old 05-24-2008, 04:16 PM #9
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Default Coming late- sorry

On the subject of tremor, has anyone else noticed that it has a regular periodicity (sp?) in the same way that a machine rotating but slightly out of balance might show. As though two waves that were supposed to match each other were slightly out of phase such that they properly aligned at a given interval. Does that make sense?

Taking that a little further- While the tremor might have a period of a second or so, there are longer cycles too . Circadian ones in particular. I have noticed that if I get up at 4 AM it is a much harder thing to deal with than if I get up at 5 AM. In a normal person this is when the body is getting ready for the day and cortisol levels are rising. But PWP don't do that and, instead, have a higher but flatter level 24/7. Anyone else noticed something similar?

Finally, iMark, you might want to download the program "Brainwave Generator" and experiment a little. Google it. It generates a sound wave of a frequency and pattern you choose and your brain entrains its own waves to match. Sort of a poor man's DBS.

I have had good success with dystonia and moderate with tremor. But there are a lot of frequencies I haven't tried. If you decide to try it let me know and I will tell you the specifics. It is pretty neat to watch the foot relax in three minutes.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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