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05-22-2008, 09:58 AM | #1 | ||
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In my case it doesn't seem to help. The following paper also confirms this.
What is your experience? http://www.springerlink.com/content/w320115652210q61/ Alessandro Agnoli1, Massimo Casacchia1, Stefano Ruggieri1, Federico Volante1 and Neri Accornero1 (1) 1a Clinica delle Malattie Nervose e Mentali, State University of Rome, Rome, Italy Received: 27 March 1972 http://www.springerlink.com/content/w320115652210q61/ Summary Tremor is among the parkinsonian symptoms one of the most difficult to control. Even the treatment by l-DOPA does not give satisfactory results. According to recent biochemical hypothesis, a loss of functional balance of cerebral serotonin and histamine seems to be responsible for the symptom. The results obtained by the administration of antihistaminic, antiserotoninic, antiaminic and acetylcholinic drugs were quantitatively compared by using a piezoelectric accelerometer. The antihistaminic drug is found to be very active but unfavourable side effects are present, while the antiaminic drug is not less active, with the advantage of being free of such effects. Key words Parkinson-Tremor - Tremor in Parkinson - Antiaminic Drugs - l-DOPA
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Imad Born in 1943. Diagnosed with PD in 2006. |
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"Thanks for this!" says: | lou_lou (05-23-2008) |
05-22-2008, 12:10 PM | #2 | ||
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But know what helps us the most? The nicotine patch and, for a non-drug treatment, snuggling and cuddling. I have no idea why, but it REALLY helps, every time. Maybe it's nature's way of telling us we need to quit spending so much time over trivial things and spend more time hunting and gathering!
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05-22-2008, 02:57 PM | #3 | ||
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Ldopa helps my tremor and other motor movements such as repetitive movements and initiating movement.
Apparently young onset respond well to Ldopa (allegedly), and I thought you were young onset. Shows what a weird diseae we have. Have you tried dop ags for tremor ? Neil. |
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05-22-2008, 07:15 PM | #4 | |||
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I'm young onset (dx at age 41 nine years ago). L-dopa does not help my resting tremor; I take amantadine for that; very effective for me, but does not work for everyone. In my case, L-dopa works for general fluidity of movement.
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"Thanks for this!" says: | imark3000 (05-23-2008) |
05-22-2008, 08:43 PM | #5 | ||
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"Thanks for this!" says: | imark3000 (05-23-2008) |
05-22-2008, 10:46 PM | #6 | ||
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My neuros have said that tremor is the most intractable of the Parkinson's symptoms, and one with a great deal of variability from case to case. For some people Sinemet works, for others an agonist, for others nothing works but DBS. I am not tremor dominant, but do have some tremor in my arm and leg on one side that was difficult to hold down before I got medicated, and now shows up on both sides off med. Permax, an agonist, did nothing for it. Sinemet alone covered some of it. Mirapex very nearly stopped it for several years, but the side effects finally overcame my wish for stillness. I've been taking Requip for a couple of years now, and it covers the tremor pretty well. After I had surgery on my hip, my internist had me taking extra Requip for the shakes I would get at bedtime, and it was effective for that.
Dx at 53 in 1999. Jaye |
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"Thanks for this!" says: | imark3000 (05-23-2008) |
05-23-2008, 04:13 AM | #7 | |||
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Nothing helps my tremor. It just gets worse and worse as the years go by (20 of them now).
Next year I may be reconsidering DBS once again. I get weary of sloshing drinks and having a hard time with insulin injections in the morning, and worse, threading a needle. I refuse to give up my fine needlework!!!, it is very important to me to maintain my dexterity and keep my sanity.
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"Thanks for this!" says: | imark3000 (05-23-2008) |
05-23-2008, 02:00 PM | #8 | |||
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I was dx'd with idiopathic PD 11 years ago. Tremor was my only symptom, and to this day pretty much still is. I got the variety pak: a tremor assortment you could say: one for any occasion. I could write the book on tremors.
My experience has been that sinemet does work for me most of the time, and for 10 years I had little to no problems. But I noticed recently that when my sinemet kicked in first thing in the morning that my tremor would also start....AND if I did not get moving the sinemet fueled the tremor for two more hours until it was time for more sinemet. I learned that benzodiazapines would override the tremor. so I set a very dangerous cycle into spin mode. On two occasions I went to emergency...another story. What I want to say is yes sinemet can both help or aggravate (cause) tremors. I'm currently working on a program to reduce my sinemet veeerry veeerrry slowly and carefully. Here's the kicker: sinemet is Levo-dopa and is not dopamine until the brain converts it AFTER it crosses the BBB. L-dopa can be converted to adrenaline before it ever gets a shot at being dopamine. This can cause BIG problems.. -tremors for example! If I could harness the energy I could make a good little income for myself.
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05-23-2008, 03:10 PM | #9 | ||
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Quote:
i take many supplements and 2 tea spoons of mucuna daily and no pd medication. my tremor is not severe but increased recently a bit. i doubled the mucuna dose with no effect. i am looking up (hoping) for natural means, diet or supplement to help Neil : what is dop ags?
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Imad Born in 1943. Diagnosed with PD in 2006. |
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05-24-2008, 02:37 PM | #10 | ||
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must be your youthful outlook that made me think you were a young onset (40 years old or younger)
Dop Ags are my shorthand for Dopamine Agonists, as a young onset myself I was started on dop ags alone (no ldopa), and they did the trick for a couple of years. Obviously as your responses to this point have shown, not everyone will have had the same experience, then there are the side effects, either way I wouldn't change my treatment to this point. Take care, Neil. |
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"Thanks for this!" says: | imark3000 (05-24-2008) |
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