All that I have been reading about low dose naltrexone seems to good to be true. Anybody know anything this drug?

I've been taking LDN for about 2 1/2 months, along with several other treatments. I don't know if it is what is preventing my symptoms from progressing, but I wouldn't want to give it up. Supposedly, it is more effective for MS than for PD, but I have seen ancedotal accounts of how it can stop PD progression, and that's good enough for me. It's cheap, too, so it's not a financial burden.

Tom Thanks for the info- LR

hi little rock and welcome.

we have many posts about ldn on neurotalk.

use the search feature located up toponthe blue tool bar.

most will be on the ms forum, but there were some thread recently here on pd.

LDN is not a cure..It supposedly arrests the progression of pd..All I can say about it is that we have a member who is taken it, and has not progressed in about 47 months

I have been taking a half teaspoon of cough syrup with Dextromethorphan before bedtime for about 15 months, which according to a study conducted by Dr Hong in pd induced rats, is supposed to do the same thing..I did exceptionally well for about 11 months, but I find now that I am becoming more symptomatic, and I know that I am due for another med increase..I am still doing realitively well however considering Im into my sixth year with pd

Robert, is another member who is also taking DM and he has not progressed much since he began the regimen..Im sure he and AshleyK will weigh in with their experiences..Ashley is taking LDN

are doing so on the strength of work done by Dr. J.S. Hong in which he demonstrated in animal studies that it is as effective as naltrexone in preventing the inflammation response of microglial cells thought to be the culprit in damaging dopamine-producing brain cells. Although naltrexone is relatively inexpensive, it does require a physicians's prescription, and the cough preparations containing DM do not.
Like Steve said, the claims made for naltrexone, even for MS, are that it appears to stop progression of the disease. I assume that the effectiveness we think we have seen with low-dose DM in PD is slowing of disease progression, not a cure.
My progression has been slow, as indicated by very little loss of normal gait, and fairly well-sustained stamina during the five years I have been using DM. I have required only small increases in meds (sinemet and amantadine, supplemented with CoQ10) over that time, and my neurologist is extremely happy with my history so far.
Bear in mind that I was in the earliest stages of PD when diagnosed in 2001, and may still be in what some have called the "honeymoon" period of responsiveness to sinemet.

It is probably just me and my sensitivities to drug therapies, but I tried LDN for 4.5 months (3 mg after 9 pm - was never able to get up to the optimal 4.5 mg per day) but LDN caused anxiety, panic attacks and sleep interference. I had really hoped that LDN would work for me but I had to stop using it - and once I stopped it the bad side affects also stopped. I don't want to discourage anyone from trying it but it didn't seem to work for me.

Pam

it may have to do with who made your LDN. the method of diluting one 50mg tablet in 50ml of water seems a bit sketchy to me but i know for a lot of people thats the only way they can come by ldn. make sure your phamacist knows what theyre doing in putting your LDN together, you need a quick release formulation, the right fillers and bulk naltrexone.grinding up pills doesnt help much since the pills have fillers too, put that in a capsule and youve just upped your fillers and lowered your naltrexone. i get mine from a medicine shoppe pharmacy with an inhouse QC guarentee of +/-2%. meaning whats in the bottle is within 2%of what the lable says.i know a lot of people get theirs from skips pharmacy in boca ratan, fla. via mail ordersupposedly skips has filled over 70,000 doses worth of LDN and skip lenz is one of the leading (and most supportive) pharmacists dealing with LDN.
the side effects are supposed to go away with time and include sleep disruption. i didnt have to deal with any panic attacts myself. i only had one vivid dream and that was the extent of my side effects. other stuff can include things like your SX seeming to be worse or more prominant. but these are supposed to be transitory.
being a novice LDN user myself(less than 3 months) i can only recomend you try a different pharmacy. one with a fair grasp on the concept of LDN.and keep in mind that the LDN can, for some people, take 6 months or more to show any real results. and to not be in too much of a hurry for it to work out.