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05-25-2008, 12:08 PM | #1 | |||
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Magnate
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Brazilian Journal of Medical and Biological Research
Print ISSN 0100-879X doi: 10.1590/S0100-879X2004000900003 Braz J Med Biol Res, September 2004, Volume 37(9) 1299-1302 (Short Communication) Response to the Comments of H.B. Ferraz et al. about the paper "High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients. C.G. Coimbra and V.B.C. Junqueira. Brazilian Journal of Medical and Biological Research, 36: 1409-1417, 2003" (to see Coimbra full paper click here) (to see H.B. Ferraz et al. comments click here) C.G. Coimbra1,2 and V.B.C. Junqueira3,4 1Setor de Neurologia, Hospital do Servidor Público Municipal de São Paulo, São Paulo, SP, Brasil 2Departamento de Neurologia e Neurocirurgia, and 3Disciplina de Geriatria, Departamento de Medicina, Centro de Estudos do Envelhecimento, Universidade Federal de São Paulo, São Paulo, SP, Brasil 4VITÆ - Cromatografia Líquida em Análises Clínicas S/C Ltda., São Paulo, SP, Brasil http://www.scielo.br/scielo.php?scri...rm=iso&tlng=en Response to the comments References Correspondence and Footnotes Key words: Parkinson's disease, Riboflavin, FAD, Glutathione, Iron, Hemin We have reported a steady and progressive improvement of motor capacity in 19 sporadic Parkinson's disease (PD) patients treated with high doses (30 mg orally every 8 h) of riboflavin plus elimination of dietary red meat for 6 months (1). The treatment was based on the following preliminary observations: I) 31 of 31 consecutively evaluated PD patients were found to have an altered enzyme glutathione reductase activation coefficient (EGR-AC) and low plasma levels of flavin adenine dinucleotide (FAD) compared to the internationally determined normal range of FAD (125-300) and to local non-PD patients suffering from other neurodegenerative conditions (dementia without a clinical history or computed tomography scan images compatible with stroke), and II) 19 PD patients were found to consume large quantities of red meat (2,044 ± 1,439 g/week) compared with 19 sex-matched controls of similar age from the same social environment (789 ± 509 g/week). Since all PD patients had a normal dietary content of riboflavin, we proposed that I) PD patients may be a subset of the large group of individuals (10-15% of the general population) expressing flavokinase (FK) with low substrate affinity (poor absorbers of vitamin B2; Ref. 2), and II) a high dietary red meat consumption might trigger PD in predisposed individuals (expressing altered FK). A review of the metabolic pathways requiring the participation of both vitamin B2 active forms (flavin mononucleotide and FAD) indicated that the association of low riboflavin absorption and high dietary red meat consumption (high dietary hemin production) might account for most (if not all) neurochemical changes reported in PD including glutathione depletion, impaired mitochondrial complex I activity, mtDNA mutations, disturbed iron metabolism, and 6(OH)dopamine formation (1). READ entire findings...
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You're alive. Do something. The directive in life, the moral imperative was so uncomplicated. It could be expressed in single words, not complete sentences. It sounded like this: Look. Listen. Choose. Act. ~~Barbara Hall I long to accomplish a great and noble tasks, but it is my chief duty to accomplish humble tasks as though they were great and noble. The world is moved along, not only by the mighty shoves of its heroes, but also by the aggregate of the tiny pushes of each honest worker. ~~Helen Keller |
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05-25-2008, 12:22 PM | #2 | ||
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In Remembrance
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wowee wow!
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paula "Time is not neutral for those who have pd or for those who will get it." |
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05-25-2008, 04:19 PM | #3 | |||
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In Remembrance
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Those pesky B vitamins keep turning up.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. Last edited by reverett123; 05-25-2008 at 04:32 PM. Reason: not reading the initial post closely :-) |
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05-25-2008, 10:45 PM | #4 | |||
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Member
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who's skills in the written word are well known.....sums it up nicely. and of course Rick--not unknown for his analytical thinking adds his colour to the equation.......Again........good stuff.
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The true leaders of today are those who strive for a world where it's every citizen can enjoy the benefits of scientific enlightenment and technological progress. GO HARD>>>>SCIENCE |
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05-26-2008, 09:39 AM | #5 | |||
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In Remembrance
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http://living.amuchbetterway.com/200...wner-cows.html
what are downer cows? a very creul reality watch youtube if you can w/o shaking! rated R for reality is vicious! http://www.youtube.com/watch?v=jaWYRFJPbtY and in the Bible -the old testement book of Leviticus Chapter's 11-12: http://tinyurl.com/4org4d the laws God gave for health reasons...
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with much love, lou_lou . . by . , on Flickr pd documentary - part 2 and 3 . . Resolve to be tender with the young, compassionate with the aged, sympathetic with the striving, and tolerant with the weak and the wrong. Sometime in your life you will have been all of these. |
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05-26-2008, 09:44 AM | #6 | |||
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In Remembrance
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http://www.pbs.org/wgbh/pages/frontl...ws/pollan.html
... [Cows] can take this grass which we can't digest, very few creatures can digest, and turn it into [fuel]. What is so amazing about that? this is a must read -please!
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with much love, lou_lou . . by . , on Flickr pd documentary - part 2 and 3 . . Resolve to be tender with the young, compassionate with the aged, sympathetic with the striving, and tolerant with the weak and the wrong. Sometime in your life you will have been all of these. |
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