What Ive been wondering is this..DM is a dopamine reuptake inhibitor..I wonder if it causes the Sinamet to work more efficiently

But what really got my interest was the "warning" about resensitizing of the receptor system. One way to skin the PD cat is to flood the system with dopamine figuring some will get through. That's more or less the sinemet approach.

The other is to optimize the receptor sensitivity and make a little dopamine go farther, which may be what is happening in part.

-Rick

has a brief explanation of LDN action based on previous work by Dr. Zagon and may also be what happens with low-dose DM. It goes something like this:
The small dose of of this opioid antagonist blocks certain opioid receptors for a short period of time just before the period of sleep in which the endorphins such as methionine enkephalin are produced by the adrenal and pituitary glands. This short inhibition stimulates increased production of endorphins and their opioid receptors in the brain.

If you want to read the actual text, here is the link to the site.
http://www.lowdosenaltrexone.org/index.htm
Since the endorphins and enkephalins are our natural "feel good" hormones, and are involved in regulating a varitey of cells of the immune system such as brain microglia, this combination of effects may be at the bottom of both Steve's lift in mood and the neuroprotection we are hoping for.
Robert

Stupid question: Would a combination of a teaspoon of cough syrup and taking a Malatonin tablit help you fall asleep faster?

Vicky

There are no stupid questions.
I don't think the cough syrup would help one fall asleep, at least at the very small doses that I take.
A single dose of melatonin probably would not either. Melatonin apparently is helpful in resetting our circadian "clock" in the case of jet lag.
It worked for me last Spring when I travelled to Greece, Turkey and Israel, especially on the return to the US from Israel.
I continued taking the DM syrup through that time and did not notice any effect of combining DM and melatonin.

Robert

How's your experiment going?
-Rick

Hi Rick..This has been a bad week to take notes..I came down with a real bad stomach bug on Sunday thats been going around which amounts to a real bad case of Montezuma's Revenge..Im still weak from it and didnt leave the house untill Wednesday..(yesterday)....But throughout it all I still had more movement ability than I had before I began the DM regimen, except for last night..I felt well enough to get out of the house and I got so carried away with household chores etc that I neglected because of the sickness, that I completely forgot to take my meds at 2:00 in the afternoon..I took a nap at 4:00, and got up at around 6:00, and went and reached for my bathrobe with my bad arm so that I could hit the shower, and the arm was stiff, and I realized why, so I went and grabbed my daily med container, and there were Wednesday afternoons meds still in it..Actually I noticed a difference when I was getting out of bed..I felt like I had broken the chain, and the meds didnt rescue me..I was stiff and weak last night..Today I went out grocery shopping and picked up my income taxes, and rested for the remainder of the day..I am still weak from that stomach bug, but my movements are reasonably fluid today..Ive noticed that I can screw and unscrew a soda bottle cap with much more ease than before I started taking the DM..Basically Ive been resting all week because I was so sick Sunday and Monday I fear relapse..I would honestly say that inspite of being sick all week my pd symptoms werent as bad as they probably would have been otherwise

Steve

Are Amantadine, Sinemet (generic), or Mirapex ok to take with dextromethorphan? Or are they MAO inhibitors?

Ann

The most common MAO inhibitors prescribed for PD are Eldepryl (selegiline) and Azilect (rasagiline). Several other MAOIs may be prescribed for a variety of other medical conditions. To be sure, check with your pharmacist about other meds you may be taking.

I left Amantadine off. It is not a MAOI either.