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06-14-2008, 01:45 AM | #1 | |||
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In Remembrance
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Pity we can't find something to stop PD in 10 minutes!!
Ron http://health.usnews.com/articles/he...excessive.html Boosting Brain Protein Quickly Cut Excessive Drinking New approach stopped desire to imbibe in as little as 10 minutes, animal study finds Posted June 13, 2008 FRIDAY, June 13 (HealthDay News) -- Boosting the level of a specific brain protein may rapidly halt excessive alcohol consumption, according to a new study done in animals. University of California, San Francisco, researchers found that the excessive amounts of GDNF, or glial cell-derived neurotrophic factor, stopped the desire to drink alcohol in as little as 10 minutes when tested on rats. Other rodents that had been "rehabbed" to give up alcohol also did not suffer a relapse into heavy imbibing when reintroduced to alcohol and given a GDNF boost. Related News Video: Health News & Features Join a Discussion More from Health GDNF shows additional promise, because it does not appear to have any side effects or block other more normal "pleasure-seeking behaviors," such as craving sweets, the researchers report. "Alcoholism is a devastating and costly psychiatric disease with enormous socioeconomic impact," senior study author Dorit Ron, the principal investigator at the UCSF-affiliated Ernest Gallo Clinic and Research Center, said in a prepared statement. "There is a tremendous need for therapies to treat alcohol abuse." "Unfortunately, only three drugs are currently approved to treat excessive drinking, and all have serious limitations. Our findings open the door to a promising new strategy to combat alcohol abuse, addiction and especially relapse," he said. Gallo researchers reported in 2005 that increased levels of GDNF appeared to cut the craving for alcohol, but they did not know how fast or effective it might be. GDNF is also being studied as a treatment for Parkinson's disease. The researchers are searching to find whether any FDA-approved drugs might stimulate GDNF activity in the brain. Only one orally delivered drug, developed for experiments in the pursuit of Parkinson's treatments, has been shown to raise brain GDNF levels in rats. The findings were published in this week's Proceedings of the National Academy of Sciences. More information
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Diagnosed Nov 1991. Born 1936 |
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"Thanks for this!" says: | lou_lou (06-14-2008) |
06-14-2008, 06:37 AM | #2 | |||
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Senior Member
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any way to determine the source of the GDNF utilized in this study?
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In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices. ~ Jean-Martin Charcot The future is already here — it's just not very evenly distributed. William Gibson |
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06-14-2008, 09:21 AM | #3 | ||
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In Remembrance
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The full text article states " GDNF was purchased from R&DSystems. "
We've been told scientists can purchase the protein, but for animal use only - there are different grades apparently. Only Amgen's could be used in humans. paula
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paula "Time is not neutral for those who have pd or for those who will get it." |
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06-14-2008, 09:43 AM | #4 | |||
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In Remembrance
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Ginseng increases GDNF output. I wonder how many other botanical sources there might be?
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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