FAQ/Help |
Calendar |
Search |
Today's Posts |
07-23-2008, 04:53 AM | #1 | |||
|
||||
Senior Member
|
Implications for the Amgen aborted study?
http://www.eurekalert.org/pub_releas...-ntf071608.php Neuronal Death Path Li-ying Yu, Mart Saarma, and Urmas Arumäe Programmed cell death pathways are generally divided into two broad categories: the intrinsic pathway, in which cellular stress (e.g., oxidative stress) leads to release of cytochrome c from mitochondria, which leads to activation of caspase-9, which activates effector caspases that degrade cellular proteins; and the extrinsic pathway, in which extracellular ligands bind to death receptors, which activate Fas-activated death domain (FADD) protein, which leads to activation of caspase-8, which activates effector caspases. This week, Yu et al. describe the apoptosis pathway activated by withdrawal of GDNF and BDNF from cultured midbrain dopaminergic neurons. The normal intrinsic pathway was not involved, because cytochrome c was not released from mitochondria. Nonetheless, caspase-9 was involved. Death-receptor pathways were also involved, because blocking FADD or caspase-8 prevented apoptosis. Interestingly, this apoptosis pathway is different than that induced by withdrawal of GDNF from sympathetic neurons.
__________________
In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices. ~ Jean-Martin Charcot The future is already here — it's just not very evenly distributed. William Gibson |
|||
Reply With Quote |
|
|
Similar Threads | ||||
Thread | Forum | |||
BDNF used to repair brain after cerebral lesion | Parkinson's Disease | |||
icky....hate withdrawl | Bipolar Disorder | |||
Sirtuin 2 inhibitor, neuronal cell death and alpha synuclein | Parkinson's Disease | |||
Exercise and the Brain and BDNF? | Parkinson's Disease | |||
Feel Really Weird right now - Shakiness, nausea, faintgness- withdrawl? | Bipolar Disorder |