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Carbon Nanotube-Coated Electrodes Improve Brain Readouts

By Laura Mgrdichian, Nanotechnology / Bio & Medicine

http://www.physorg.com/news137768659.html

A research group has significantly improved the quality of brain-function measurements by coating metal neural electrodes with carbon nanotubes. Their work could potentially allow scientists to learn more about brain diseases that are based on electrical impulse malfunctions, such as Parkinson's and epilepsy.

One limitation of current machines used to record brain signals are the electrodes: They have a natural resistance to electric current, called impedance, which compromises their ability to produce sensitive readouts. The impedance also makes the machines less effective at putting out charge when they are being used to simulate brain-cell activity via neurons in culture.

Coating the electrodes with carbon nanotubes, which have excellent electrical properties, offers a solution to both problems, discovered Edward Keefer, of the University of Texas Southwestern Medical School, and colleagues from the Texas Scottish Rite Hospital for Children, Vanderbilt University, and the University of North Texas.

"Modulation of brain activity to provide symptomatic relief from growing number of diseases such as Parkinson's, depression, and epilepsy has become the treatment of choice when all other options fail," Keefer told PhysOrg.com. "The interface between the cells of the brain and the surface of the implanted electrode determines whether these treatments work or not. By coating electrode surfaces with carbon nanotubes, we can improve the efficiency of this cell-electrode interface by one-thousand times or even more."

Keefer compared the improvement in nanotube-coated electrodes over standard electrodes to the difference between watching your favorite show on a 13-inch black-and-white television with a broken antenna or a brand-new 60-inch, high-definition, satellite-fed model.

"For an electrophysiologist, that is the difference the nanotube-coated electrodes make in what we can see on our oscilloscopes," he said.

The electrodes they tested were commercial varieties made of tungsten and stainless steel wire, which are thin and sharp. In two animal samples—the motor cortex of rats under anaesthesia and the visual cortex of awake rhesus macaque monkeys—the group took readouts with a nanotube-coated electrode and a non-coated electrode, and compared the results.

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