I know everyone who reads this is thinking, what is it and when? And will it be available, as in, publicly available to anyone who needs it and not just those in trials in five years? Also, will it be available everywhere in five years, or just in Europe/France? Any information you can share would be most appreciated, particularly if what you are referencing is prosavin, which has been talked about on this forum. Thanks!

this is the tri genetic therapy,i am reffering:
[QUOTE]Gene Therapy Success for Parkinson's
Research in monkeys suggests that genetically delivering dopamine avoids some side effects.
By Emily Singer
http://www.technologyreview.com/blog/editors/24236/

According to an article on the NatureNews website:
http://www.nature.com/news/2009/0910...2009.1001.html

...Palfi's technique is not the only gene therapy currently being pursued for Parkinson's disease. Some researchers are delivering genes that provide growth factors to halt the death of dopamine-producing neurons. Others are introducing genes that inhibit the excessive neural activity associated with Parkinson's disease in the same way as the surgical process known as deep-brain stimulation. And yet others are focusing on single genes -- rather than all three -- with a role in dopamine synthesis.

But Palfi's team is the first to deliver all three of the dopamine genes in a single viral vector in primates. This approach aims to eliminate the need for L-DOPA and its associated side effects.

what makes this genetic therapy a cure is that the brain produces dopamine at a sufficient level again........

6 humans patients have been treated already..with very good results

the bad side is that for the moments ,laboratory can produce genes in small quantities but not ready yet for"mass production ".......

from "le FIGARO ",the biggest french newspaper,here is the article :
http://www.lefigaro.fr/sante/2009/10...ometteuse-.php

*

from what he told me,they are still searching for the most efficient genes doses to inject,6 human patients were treated last year,12 would receive the therapy in 2010.

I am 40, i asked him to be on the next waiting /experiment list...but they work with much older patients for now .
5 years time is when the treatment should be available to everybody .
In the french press,there was much fuss about this discovery,and some articles suggested 3 years .
prof Palfi told me 5 years......
in the french article ,it's written that one of the big monkey,48 months after his genes injection, was still in great dopa shape.......

Is this doctor involved in the prosavin trials?

Professor Stéphane Palfi commented : "The preclinical proof-of-concept studies together with clinical data from the first two dose levels in the Phase I/II study suggest that ProSavin may provide sustained and meaningful benefit to patients and could reduce or eliminate the debilitating complications associated with oral dopamine replacement therapy. In the initial indication of moderate to late-stage Parkinson's disease, ProSavin potentially offers significant advantages to the current alternatives of Deep Brain Stimulation or mechanical delivery of continuous dopamine."

Read more: http://www.fiercebiotech.com/press-r...#ixzz0etMcD06V

[QUOTE=jeanb;619072]Professor Stéphane Palfi commented : "The preclinical proof-of-concept studies together with clinical data from the first two dose levels in the Phase I/II study suggest that ProSavin may provide sustained and meaningful benefit to patients and could reduce or eliminate the debilitating complications associated with oral dopamine replacement therapy. In the initial indication of moderate to late-stage Parkinson's disease, ProSavin potentially offers significant advantages to the current alternatives of Deep Brain Stimulation or mechanical delivery of continuous dopamine."


i think he is ProSavin too.

[QUOTE=villiers;619098]Hi Villiers

I met Dr Palfi last year in London at a conference at the Royal Holloway. He was very enthusiastic about Prosavin. I asked him at the time that the results may have been down to placebo, but he assured that he felt it was not. I understand they are about to start the next stage of the trials which will involve using something called convection enhanced delivery. This should allow them to use higher more efficaeous doses. Their current low doses have achieved similar results to DBS without the need for wires to be left in the brain.

Did Dr Palfi tell you anything else about Prosavin? Is he still optimistic about its future?

cheers

Martin

[QUOTE=MartinC-J;640985]Hello Martin

Dr Palfi seemed very optimistic .
He told me that in 5 years,this treatment would be largely available
(i met him in dec 09)
He was kindda secretive about it too
i begged him to be part in the upcoming trials
but it seems i am not enough "old" to be involved (i am 40)

As a person,he was very cold and arrogant

my meeting with him took place at HOPITAL HENRI MONDOR IN CRETEIL (a suburb of Paris )
I could get an appointment by phone
cost 23 euros
cheers

and there 2009 report says:

"Prosavin currently has shown a stable approximate 30% improvement in the patient's condition, regardless of dose level. At 30% improvement in larger trials it will likely challenge deep brain stimulation for the surgery market in Parkinson's disease".

So not a cure, still early days, (Spheramine failed much later than the stage at which Prosavin is currently), and Oxfordbiomedica see Prosavin as coming to market 2012/2013, if it passes trials and they get a partner as they cannot afford this to go alone, etc, yadda yadda ...

Remember, they all work on monkeys and rats and until the tests are blinded, (at this rate I might have that on my gravestone).

Sorry, just trying to spread a little realism here.

Neil (aka misery of Evesham).