Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 10-12-2008, 08:32 PM #1
olsen's Avatar
olsen olsen is offline
Senior Member
 
Join Date: Aug 2006
Posts: 1,860
15 yr Member
olsen olsen is offline
Senior Member
olsen's Avatar
 
Join Date: Aug 2006
Posts: 1,860
15 yr Member
Default significant CoEnzyme Q10 deficit in brains of PD patients

Neurosci Lett. 2008 Sep 30. [Epub ahead of print] Links
The coenzyme Q(10) status of the brain regions of Parkinson's disease
patients.Hargreaves IP, Lane A, Sleiman PM.
Department of Molecular Neuroscience, Institute of Neurology, Queen
Square, London WC1N 3BG, UK.

There is increasing evidence that impairment of mitochondrial
function and oxidative damage are contributing factors to the
pathophysiology of Parkinson's disease (PD). Studies have reported
decreased levels of the mitochondrial electron transport chain
carrier, coenzyme Q(10) (CoQ(10)) in plasma and platelets from PD
patients. Although a deficit in peripheral CoQ(10) has been reported
no studies have assessed the CoQ(10) status of the PD brain. In this
study we investigated the CoQ(10) status of the substantia nigra,
cerebellum, cortex and striatum brain regions of both PD patients and
age-matched controls. The results of this study indicate a
significant reduction (p=0.007) in CoQ(10) concentration in the
cortex region of the brain. In conclusion, the results of this study
indicate evidence of a deficit in brain CoQ(10) status may be
involved in the pathophysiology of PD.

PMID: 18840506 [PubMed - as supplied by publisher]
__________________
In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices.

~ Jean-Martin Charcot


The future is already here — it's just not very evenly distributed. William Gibson
olsen is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
mrsD (10-13-2008), Shake 'Em Up (10-13-2008)
Old 10-13-2008, 04:52 AM #2
olsen's Avatar
olsen olsen is offline
Senior Member
 
Join Date: Aug 2006
Posts: 1,860
15 yr Member
olsen olsen is offline
Senior Member
olsen's Avatar
 
Join Date: Aug 2006
Posts: 1,860
15 yr Member
Default statins and coQ10 levels

FYI: all statin drugs (anti cholesterol--Lipitor, zocor, crestor, pravachol) interfere with the production of coenzyme Q10. coQ10 plasma, platlet and muscle tissue levels are decreased in patients who take statins, all patients, whether or not they have any conditions other than high cholesterol.
__________________
In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices.

~ Jean-Martin Charcot


The future is already here — it's just not very evenly distributed. William Gibson
olsen is offline   Reply With QuoteReply With Quote
Old 10-14-2008, 11:04 AM #3
jcitron jcitron is offline
Member
 
Join Date: Sep 2007
Location: Haverhill, MA
Posts: 480
15 yr Member
jcitron jcitron is offline
Member
 
Join Date: Sep 2007
Location: Haverhill, MA
Posts: 480
15 yr Member
Default

Quote:
Originally Posted by olsen View Post
FYI: all statin drugs (anti cholesterol--Lipitor, zocor, crestor, pravachol) interfere with the production of coenzyme Q10. coQ10 plasma, platlet and muscle tissue levels are decreased in patients who take statins, all patients, whether or not they have any conditions other than high cholesterol.
Interesting point here. I had very few symptoms until after I had a reaction to Lipitor. Ever since that time in 2003/2004, I've gone down hill. There's no way to prove the link so I wonder if this was an underlying problem all along and the Lipitor "helped" it come to the forefront.

John
jcitron is offline   Reply With QuoteReply With Quote
Reply


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Chiari malformation and attention deficit disorder daisy1959 New Member Introductions 12 08-08-2013 12:48 AM
Dystonic Tremor without Dopamine Deficit ZucchiniFlower Parkinson's Disease 0 02-18-2008 04:02 PM


All times are GMT -5. The time now is 06:18 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.