"Overexpression of alpha-synuclein (SNCA) in families with multiplication mutations causes parkinsonism and subsequent dementia, characterized by diffuse Lewy Body disease post-mortem. Genetic variability in SNCA contributes to risk of idiopathic Parkinson's disease (PD), possibly as a result of overexpression.

SNCA downregulation is therefore a valid therapeutic target for PD.

Results: We have identified human and murine-specific siRNA molecules which reduce SNCA in vitro.

As a proof of concept, we demonstrate that direct infusion of chemically modified (naked), murine-specific siRNA into the hippocampus significantly reduces SNCA levels..."

Here's the link:

http://7thspace.com/headlines/296739...ked_sirna.html

There is another article on google news but unfortunately, it's in German, which is way beyond my liguistic abilities!