Hi Rick,
the soluble option is something I have read about over and again, right through to the best things in which to dissolve our 'gold standard' stuff in, seems to be something that many people here and elsewhere tried, I have tried it myself, but do not rate myself as having an overwhelming need to and found it a bind to keep to a regular schedule. I do not know how much relief this brings for random offs, but my first response to your post was that there would not be any money to be made from it ..... I don't however think that this is what you were getting at, but it does not bypass digestive system either......

Lindy

Robert,
You were right, it was the transport log jam. Since I stopped the tyrosine 3 days ago, I don't now need to fear my sinemet wearing off. I now don't get the totally disabling off I was getting. Thanks for your input.
Lindylanka,
For a long time I was very interested in nasal delivery of levodopa.
There is a channel in the nose which connects directly to the brain, and by-passes the BBB. I corresponded with a UK company, who were developing the route using a nasal spray.
see
http://www.in-pharmatechnologist.com...-drug-delivery
also
http://www.ingentaconnect.com/conten...4?crawler=true
A huge advantage is it is much faster acting, not having to go through the gut absorbtion stage. However, there are a few too many hurdles and they dropped it. I even tried a few experiments myself, but you need no carbidopa present, otherwise it would prevent your brain levodopa from being converted to dopamine.
Ron

Have a look at
http://myheartmind.blogspot.com/2008...teins-for.html
where it says
"To further complicate matters, amino acids are assigned a particular "truck." Amino acids in the same group compete for the limited space in that transport molecule. For example, the amino acids tryptophan and tyrosine both belong in the same category and must enter your brain together. If tryptophan dominates, your neurons will make more serotonin, the calming neurotransmitter that promotes contentment and is responsible for normal sleep. If tyrosine wins out, then you will synthesize more norepinephrine and dopamine, stimulating neurotransmitters that promote alertness and activity.

Tyrosine is crucial to brain power and alertness in another way. It's also needed for your body to make active thyroid hormones. Therefore, low blood levels of tyrosine are associated with an underactive thyroid gland. An extreme deficiency causes severe mental retardation known as cretinism."

Ron

Bumping this thread up for Ibby for info on problems with sinemet and supplementing witih tyrosine.