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12-10-2008, 09:18 AM | #1 | ||
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having seen a post from Lurking in Rick's "crawling thread" posing the above question, I began to wonder if we had moved forward the debate over neuron death versus neuron recession. This was mentioned by Daffy some time ago in the thread :
http://neurotalk.psychcentral.com/thread6226.html Whats the latest word from research, are our brain cells dying or lying dormant ? Neil. |
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12-10-2008, 11:47 AM | #2 | ||
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I havenot seen anything conclusive about this debate yet. I sort of check on the web for that info and ask my neurologist whenever I see her/
My own bias is that neurons are asleep or atleast lazy and dont hear the alarm! If they were all dying, treatment with agonists would not work. girija Quote:
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12-10-2008, 02:35 PM | #3 | |||
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Neil,
Good question - I think one of the hopes of Isradipine (calcium channel blocker) is that by blocking the calcium from irritating the (non-)dopamine producing cells, that those cells would (eventually) rejuvenate - and start producing dopamine again. (I'm not sure what stage the clinical trial for Isradipine is in now) I've been taking Isradipine for about 18 months now - and nothing miraculous for me so far. But what if this works but it takes 5 years before the cells start repairing themselves? I'm in it for the long haul. I still have hope for this to work. (I'm a "white lab rat" -- but my neurologist is happy to prescribe Isradipine since I have hypertension. Who would have imagined that would be a good thing?)
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Jean B This isn't the life I wished for, but it is the life I have. So I'm doing my best. Last edited by jeanb; 12-10-2008 at 02:37 PM. Reason: forgot something |
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12-11-2008, 02:14 AM | #4 | |||
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I think the main evidence for assuming death of the dopaminergic neurons is the loss of tyrosine hydroxylase-positive cells in PD substantia nigra observed post-mortem, compared to normal post-mortem SN. Also, the progressive loss of dopamine re-uptake as indicated by PET and SPECT data with labeled fluorodopa and beta CIT suggests cell death.
Robert |
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